{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:07:56Z","timestamp":1789726076263,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"52","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA1210201"],"award-info":[{"award-number":["2024YFA1210201"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2510000"],"award-info":[{"award-number":["2023YFC2510000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFF1202804"],"award-info":[{"award-number":["2022YFF1202804"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373018"],"award-info":[{"award-number":["82373018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473295"],"award-info":[{"award-number":["82473295"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Glioblastoma multiforme (GBM) remains largely incurable due to the blood\u2010brain barrier (BBB) and immunosuppressive microenvironment. While boron neutron capture therapy (BNCT) selectively eradicates tumor cells via\n                    <jats:sup>10<\/jats:sup>\n                    B(n, \u03b1)\u2010\n                    <jats:sup>7<\/jats:sup>\n                    Li reactions, its clinical potential in GBM is unrealized because of the suboptimal pharmacokinetics of conventional boron agents and their failure to achieve therapeutic intracranial concentrations. Here, we design macrophage membrane\u2010coated PLGA nanoparticles (M@PLGA\u2010\n                    <jats:sup>10<\/jats:sup>\n                    BN) that exploit innate biological transport mechanisms to overcome dual therapeutic barriers. The macrophage membrane enables: (i) \u03b1\n                    <jats:sub>4<\/jats:sub>\n                    \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    integrin\u2010mediated BBB transmigration via VCAM\u20101 binding, (ii) chemokine\u2010directed tumor tropism, and (iii) CD47\u2010dependent immune evasion. In orthotopic GL261 gliomas, M@PLGA\u2010\n                    <jats:sup>10<\/jats:sup>\n                    BN delivers 53.15\u00a0\u00b5g\/g\n                    <jats:sup>10<\/jats:sup>\n                    B to tumors \u2013 3.09\u2010fold higher than uncoated nanoparticles \u2013 with tumor\u2010to\u2010normal\/brain (T\/N) and tumor\u2010to\u2010blood (T\/B) ratios of 3.95 and 3.85, respectively. Neutron irradiation extends survival by 50 days and triggers immunogenic cell death, increasing tumor\u2010infiltrating CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells 4.2\u2010fold while reducing regulatory T cells (Tregs) by 68%. Crucially, BNCT\u2010induced PD\u2010L1 upregulation provides a mechanistic basis for combining with anti\u2010PD\u20101 immunotherapy, achieving complete tumor regression in 50% of mice. By concurrently overcoming the blood\u2010brain barrier and immunosuppression, this biomimetic strategy unlocks new clinical horizons for BNCT, establishing a new paradigm for treating CNS malignancies.\n                  <\/jats:p>","DOI":"10.1002\/advs.76216","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T11:19:57Z","timestamp":1782127197000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomimetic Macrophage Cell Membrane\u2010Based Nanoparticles for Effective Treatment of Glioblastoma Through Boron Neutron Capture Therapy Combined With Immunotherapy"],"prefix":"10.1002","volume":"13","author":[{"given":"Jiawen","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital Fudan University  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"You","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics School of Pharmaceutical Sciences Key Laboratory of Smart Drug Delivery Ministry of Education State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center For Brain Science Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hefa","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Nuclear Science and Technology Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital Fudan University  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruize","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital Fudan University  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital Fudan University  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qisheng","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital Fudan University  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianwen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital Fudan University  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1015-126X","authenticated-orcid":false,"given":"Shan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital Fudan University  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2878-0913","authenticated-orcid":false,"given":"Houshi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital Fudan University  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital Fudan University  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital Fudan University  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoyuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital Fudan University  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beining","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital Fudan University  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital Fudan University  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulai","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital Fudan University  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqiu","family":"Ping","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital Fudan University  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlin","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital Fudan University  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songlin","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital Fudan University  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghui","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai ImmunoBiotech Co., Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Gu","sequence":"additional","affiliation":[{"name":"School of Nuclear Science and Technology Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1049-1216","authenticated-orcid":false,"given":"Tao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics School of Pharmaceutical Sciences Key Laboratory of Smart Drug Delivery Ministry of Education State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center For Brain Science Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifeng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital Fudan University  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noac202"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010022\u201002349\u20107"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010022\u201000475\u20100"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010025\u201002299\u20104"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21964"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2025.123435"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10837450.2024.2406044"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes14010127"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202402307"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2021.1938756"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.01.043"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.108875"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.2c01863"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202301861"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202400514"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2005.10.010"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9070722"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202301479"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn1006495"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2013.01.070"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13936"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2022.101558"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202100969"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.788770"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059639"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/d5tb00478k"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202419418"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15133277"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.114257"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/17435889.2025.2503694"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201029780\u2010w"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202214145"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.12.036"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4nr00284a"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202405158"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.11.017"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.2217\/NNM.14.25"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10876\u2010020\u201001811\u2010w"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmm2.12068"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158249"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2020.110964"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb14040181"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.34133\/bmr.0343"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17121613"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.12.037"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40843\u2010025\u20103740\u2010y"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095\u2010017\u20102257\u20105"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c09033"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40242\u2010025\u20105042\u20108"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.76216","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.76216","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.76216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:33:51Z","timestamp":1789724031000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.76216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,22]]},"references-count":49,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/advs.76216"],"URL":"https:\/\/doi.org\/10.1002\/advs.76216","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,22]]},"assertion":[{"value":"2025-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e76216"}}