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In particular,\n                    <jats:italic>Veillonella parvula<\/jats:italic>\n                    (\n                    <jats:italic>V. parvula<\/jats:italic>\n                    ) supplies essential nutrients to the keystone pathogen\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    , enabling its virulence even at low abundance. Therefore, targeting\n                    <jats:italic>V. parvula<\/jats:italic>\n                    nitrate metabolism to deprive\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    of nutrients and attenuate its virulence represents a promising therapeutic strategy for controlling periodontitis progression. We engineered L\u2010cysteine\u2010capped ruthenium nanoclusters (Ru NCs) that efficiently reduce nitrate to ammonium under 660\u00a0nm light. This photocatalytic conversion depleted the bioavailable nitrate pool associated with\n                    <jats:italic>V. parvula<\/jats:italic>\n                    metabolism, disrupting amino acid production and quorum\u2010sensing\u2010related support for\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    . Consequently, Ru NCs potently reduced biofilm biomass and thickness, suppressed\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    activity, and downregulated its key virulence genes\n                    <jats:italic>(RgpA\/B<\/jats:italic>\n                    ,\n                    <jats:italic>Kgp<\/jats:italic>\n                    ,\n                    <jats:italic>FimA<\/jats:italic>\n                    ). Multiomics analyses supported nitrate\u2010dependent metabolic collapse in\n                    <jats:italic>V. parvula<\/jats:italic>\n                    , which was associated with downstream energy and biosynthetic impairment in\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    . In a rat periodontitis model, light\u2010activated Ru NCs attenuated alveolar bone loss, preserved collagen, and shifted the local cytokine profile from pro\u2010inflammatory (IL\u20106) to anti\u2010inflammatory (Arg\u20101). This work provides a proof\u2010of\u2010concept strategy for targeting defined interspecies metabolic interactions, offering a new paradigm for microbiome\u2010targeted therapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.76245","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T19:39:58Z","timestamp":1782157198000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Light\u2010Activated Ruthenium Nanoclusters Reprogram the Metabolic\u2010Quorum Sensing Axis for Precision Periodontitis Therapy"],"prefix":"10.1002","volume":"13","author":[{"given":"Jing","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Oral Implantology Hospital of Stomatology Jilin Provincial Key Laboratory of Sciences and Technology for Stomatology Nanoengineering Jilin University  Changchun 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