{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:07:16Z","timestamp":1789726036314,"version":"4.0.1"},"reference-count":72,"publisher":"Wiley","issue":"52","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2705605"],"award-info":[{"award-number":["2023YFC2705605"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20402"],"award-info":[{"award-number":["U23A20402"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471652"],"award-info":[{"award-number":["82471652"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371628"],"award-info":[{"award-number":["82371628"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201773"],"award-info":[{"award-number":["82201773"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22574175"],"award-info":[{"award-number":["22574175"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401885"],"award-info":[{"award-number":["82401885"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ30731"],"award-info":[{"award-number":["2023JJ30731"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2025JJ50602"],"award-info":[{"award-number":["2025JJ50602"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The precise assembly of the sperm flagellum is essential for male fertility and has long been ascribed to kinesin\u20102\u2013driven intraflagellar transport (IFT) of protein cargoes. However, during late spermiogenesis, when transcription activity is largely silenced, how the spatiotemporally regulated delivery of flagellar components remains poorly understood. Here, we systematically screened kinesin genes in asthenozoospermic patients and identified two homozygous deleterious\n                    <jats:italic>KIF6<\/jats:italic>\n                    variants in unrelated men characterized by complete sperm immotility. Mouse models carrying the corresponding mutations recapitulated the human infertility phenotypes. Multi\u2010omics analyses revealed that most testicular mRNAs remained largely unchanged in\n                    <jats:italic>Kif6<\/jats:italic>\n                    <jats:sup>M1\/M1<\/jats:sup>\n                    mice, whereas proteins involved in axonemal organization and energy metabolism were markedly reduced. Mechanistically, KIF6 interacts with the RNA\u2010binding proteins (RBPs) FMRP and FXR1 to assemble mRNP transport complexes that ferry transcripts encoding flagellar structural proteins (e.g., DNALI1) and metabolic enzymes (e.g., HK1). Impaired KIF6 function compromises mRNP trafficking to the developing flagellum, reducing flagellar transcript levels and ultimately causing decreased protein abundance and defective flagellar function. Collectively, we identify KIF6 as a key regulator of mRNA transport during spermiogenesis. It interacts with RBPs through a novel IFT\u2010like pathway to deliver mRNAs essential for flagellar biogenesis, redefining the traditional protein\u2010centric IFT paradigm.\n                  <\/jats:p>","DOI":"10.1002\/advs.76263","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T16:36:36Z","timestamp":1782405396000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The KIF6\u2010RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly"],"prefix":"10.1002","volume":"13","author":[{"given":"Chunbo","family":"Xie","sequence":"first","affiliation":[{"name":"Institute of Reproduction and Stem Cell Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"},{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive &amp; Genetic Hospital of CITIC\u2010Xiangya  Changsha China"},{"name":"NHC Key Laboratory of Human Stem Cell and Reproductive Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibing","family":"Yi","sequence":"additional","affiliation":[{"name":"Institute of Reproduction and Stem Cell Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinle","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Reproduction and Stem Cell Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Reproduction and Stem Cell Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"},{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive &amp; Genetic Hospital of CITIC\u2010Xiangya  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Reproduction and Stem Cell Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"},{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive &amp; Genetic Hospital of CITIC\u2010Xiangya  Changsha China"},{"name":"NHC Key Laboratory of Human Stem Cell and Reproductive Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Institute of Reproduction and Stem Cell Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"},{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive &amp; Genetic Hospital of CITIC\u2010Xiangya  Changsha China"},{"name":"NHC Key Laboratory of Human Stem Cell and Reproductive Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanlan","family":"Meng","sequence":"additional","affiliation":[{"name":"Institute of Reproduction and Stem Cell Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"},{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive &amp; Genetic Hospital of CITIC\u2010Xiangya  Changsha China"},{"name":"NHC Key Laboratory of Human Stem Cell and Reproductive Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Reproduction and Stem Cell Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Tan","sequence":"additional","affiliation":[{"name":"Institute of Reproduction and Stem Cell Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjia","family":"Wei","sequence":"additional","affiliation":[{"name":"Institute of Reproduction and Stem Cell Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Reproduction and Stem Cell Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoqiong","family":"Liang","sequence":"additional","affiliation":[{"name":"Institute of Reproduction and Stem Cell Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Reproduction and Stem Cell Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"},{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive &amp; Genetic Hospital of CITIC\u2010Xiangya  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Reproduction and Stem Cell Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"},{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive &amp; Genetic Hospital of CITIC\u2010Xiangya  Changsha China"},{"name":"NHC Key Laboratory of Human Stem Cell and Reproductive Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxiu","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute of Reproduction and Stem Cell Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"},{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive &amp; Genetic Hospital of CITIC\u2010Xiangya  Changsha China"},{"name":"NHC Key Laboratory of Human Stem Cell and Reproductive Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"},{"name":"College of Life Sciences Hunan Normal University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1966-5075","authenticated-orcid":false,"given":"Wenbin","family":"He","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive &amp; Genetic Hospital of CITIC\u2010Xiangya  Changsha China"},{"name":"College of Life Sciences Hunan Normal University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Reproduction and Stem Cell Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"},{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive &amp; Genetic Hospital of CITIC\u2010Xiangya  Changsha China"},{"name":"NHC Key Laboratory of Human Stem Cell and Reproductive Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"},{"name":"College of Life Sciences Hunan Normal University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5701-6703","authenticated-orcid":false,"given":"Juan","family":"Du","sequence":"additional","affiliation":[{"name":"Institute of Reproduction and Stem Cell Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"},{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive &amp; Genetic Hospital of CITIC\u2010Xiangya  Changsha China"},{"name":"NHC Key Laboratory of Human Stem Cell and Reproductive Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Reproduction and Stem Cell Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"},{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive &amp; Genetic Hospital of CITIC\u2010Xiangya  Changsha China"},{"name":"NHC Key Laboratory of Human Stem Cell and Reproductive Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"},{"name":"College of Life Sciences Hunan Normal University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5682-8948","authenticated-orcid":false,"given":"Chaofeng","family":"Tu","sequence":"additional","affiliation":[{"name":"Institute of Reproduction and Stem Cell Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"},{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive &amp; Genetic Hospital of CITIC\u2010Xiangya  Changsha China"},{"name":"NHC Key Laboratory of Human Stem Cell and Reproductive Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8359-4654","authenticated-orcid":false,"given":"Yue\u2010Qiu","family":"Tan","sequence":"additional","affiliation":[{"name":"Institute of Reproduction and Stem Cell Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"},{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive &amp; Genetic Hospital of CITIC\u2010Xiangya  Changsha China"},{"name":"NHC Key Laboratory of Human Stem Cell and Reproductive Engineering Xiangya School of Basic Medical Sciences Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00009.2020"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2009"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028290"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/biosci\/biu175"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.18352"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajb2.1010"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2021.06.010"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2021.11.022"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13828"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.12.5519"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/aja.aja_53_19"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010024\u201000797\u2010x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa004"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010024\u201000780\u20106"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3918"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010021\u201000356\u20108"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556\u2010024\u201001444\u20105"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.06.053"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2008.04.003"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.05.042"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz1588"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2536695100"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2888"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010020\u20100209\u20106"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201027298\u20101"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.09.030"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.m200037\u2010mcp200"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjy043"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.11.022"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.367606"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M112.020552"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2018.06.023"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2025.03.035"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202312060"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmab001"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.60"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.03.081"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adj8172"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq1069"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460\u20102075.1995.tb00220.x"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.7.3825"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583\u2010021\u201000432\u20100"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2774"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj6647"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.200516"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010024\u201005177\u20104"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2018355118"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.108.068882"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010023\u201005653\u2010y"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098\u20102795(199601)43"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098\u20102795(199601)43:1<82"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010024\u201007118\u20102"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.01.004"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.11.046"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2782"},{"key":"e_1_2_9_57_1","first-page":"391","article-title":"Protein Translation in Mammalian Sperm","volume":"65","author":"Gur Y.","year":"2007","journal-title":"Society for Reproduction and Fertility"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200800353"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2026.03.005"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004290050245"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004290100176"},{"key":"e_1_2_9_62_1","volume-title":"WHO Laboratory Manual for the Examination and Processing of Human Semen","author":"World Health Organization","year":"2010"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.130"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmp048"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev251"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421\u2010023\u201000580\u2010w"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1322"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.3c03357"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad0836"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu097"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaf379"},{"key":"e_1_2_9_72_1","doi-asserted-by":"crossref","unstructured":"K. J.Bowers F. D.Sacerdoti andJ. K.Salmon \u201cMolecular Dynamics\u2014Scalable Algorithms for Molecular Dynamics Simulations on Commodity Clusters \u201d inProceedings of the 2006 ACM\/IEEE Conference on Supercomputing\u2014SC \u203206(ACM Press 2006) 84 https:\/\/doi.org\/10.1145\/1188455.1188544.","DOI":"10.1145\/1188455.1188544"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00792\u20102020"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.76263","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.76263","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.76263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:32:40Z","timestamp":1789723960000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.76263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":72,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/advs.76263"],"URL":"https:\/\/doi.org\/10.1002\/advs.76263","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]},"assertion":[{"value":"2026-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e76263"}}