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Here, we identify eukaryotic translation elongation factor 1 gamma (eEF1G), highly expressed in spermatogenic cells, as a factor essential for sustaining translation during this transcriptionally quiescent period. Germ cell\u2013specific\n                    <jats:italic>Eef1g<\/jats:italic>\n                    knockout causes complete male infertility due to zygotene arrest, characterized by defects in recombination intermediate stabilization and synapsis. Mechanistically, eEF1G associates with ribosomal proteins, and ribosome profiling reveals increased ribosome occupancy on specific meiotic transcripts in\n                    <jats:italic>Eef1g<\/jats:italic>\n                    \u2010deficient spermatocytes. Quantitative proteomics further reveals selective depletion of synapsis\u2010related (e.g., SYCP1, SYCE1) and recombination\u2010related proteins (e.g., MSH4, TEX11). Together, these findings demonstrate that eEF1G is required to maintain efficient protein production during the transcriptionally quiescent leptotene\/zygotene stages, thereby supporting proper meiotic progression in mammalian spermatocytes.\n                  <\/jats:p>","DOI":"10.1002\/advs.76264","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T14:18:55Z","timestamp":1782915535000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["eEF1G Orchestrates Translation to Ensure Meiotic Progression in Transcriptionally Quiescent Spermatocytes"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6040-294X","authenticated-orcid":false,"given":"Jianze","family":"Xu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health Shandong University  Shandong P. 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