{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:05:41Z","timestamp":1789725941370,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"52","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52130309"],"award-info":[{"award-number":["52130309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["W2412081"],"award-info":[{"award-number":["W2412081"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22388101"],"award-info":[{"award-number":["22388101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22578023"],"award-info":[{"award-number":["22578023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1200900"],"award-info":[{"award-number":["2021YFA1200900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Immunogenic cell death (ICD) induced by photothermal therapy holds promise for eliciting systemic antitumor immunity; however, its efficacy is frequently limited by tumor\u2010intrinsic immunosuppressive defenses. Herein, we report a nano\u2010confined radical anion as a photothermal immunogenic amplifier that exploits kinetic stabilization to couple high NIR\u2010II photothermal efficiency with active glutathione depletion for robust in situ cancer vaccination. This amplifier is constructed through the simple co\u2010assembly of terrylene diimide (TDI) with Pluronic F127, forming nanoparticles in which stable TDI radical anions are generated and kinetically stabilized. The radical anion nanoparticles are further integrated into an injectable hydrogel to create a multifunctional in situ vaccine. This platform ensures prolonged tumor retention, captures tumor\u2010associated antigens released during ICD, and provides intrinsic adjuvanticity. In murine models, local laser activation of the platform ablates primary tumors and elicits systemic antitumor immune responses associated with suppression of distant tumor growth. The stabilization of organic radical anions by molecular and supramolecular design combines local photothermal therapy with systemic anti\u2010tumor immunity.<\/jats:p>","DOI":"10.1002\/advs.76277","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:37:54Z","timestamp":1782477474000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nano\u2010Confined Radical Anion as An NIR\u2010II Photothermal Immunogenic Amplifier for In Situ Cancer Vaccination"],"prefix":"10.1002","volume":"13","author":[{"given":"Mengxin","family":"Mu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyu","family":"Guo","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety &amp; CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Guan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingdi","family":"Hu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety &amp; CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fene","family":"Gao","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety &amp; CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6630-8786","authenticated-orcid":false,"given":"Klaus","family":"M\u00fcllen","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Polymer Research  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4913-1645","authenticated-orcid":false,"given":"Chendong","family":"Ji","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6027-0315","authenticated-orcid":false,"given":"Chunying","family":"Chen","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety &amp; CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meizhen","family":"Yin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202512470"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202503299"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202517480"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202515097J"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202424830"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201057533\u2010y"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc4373"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adq3870"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202201706"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00221"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11426\u2010024\u20102231\u20101"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2024.09.017"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c13067"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201008434\u20104"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200902532"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2SC06162G"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202300203"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010024\u201000892\u20100"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010024\u201001618\u20100"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2025.102756"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202505069"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1MH01019K"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202318530"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202204830"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00718H"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3423"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202404395"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.743"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202417678"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202210644"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202401806"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4CS00679H"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201056137\u2010w"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201004243\u20102"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202208157"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010023\u201000561\u20101"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201036920\u20103"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202412839"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c00255"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.09.010"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563\u2010022\u201001251\u2010z"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010023\u201001580\u20103"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202416390"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.76277","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.76277","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.76277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:31:42Z","timestamp":1789723902000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.76277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,26]]},"references-count":43,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/advs.76277"],"URL":"https:\/\/doi.org\/10.1002\/advs.76277","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,26]]},"assertion":[{"value":"2026-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e76277"}}