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Nonetheless, the utilization of traditional radioactive microspheres in TARE is hindered by various material and technical challenges that necessitate resolution. Herein, we present, for the first time, well\u2010designed and synthesized conjugated poly(imide dioxime) ligand\u2010based microspheres (PID\u2010Ms) with a remarkable radiometal coordinate covalent conformational interlocked network. PID\u2010Ms can be radiolabeled with various radionuclides, including\n                    <jats:sup>177<\/jats:sup>\n                    Lu,\n                    <jats:sup>90<\/jats:sup>\n                    Y,\n                    <jats:sup>188<\/jats:sup>\n                    Re,\n                    <jats:sup>68<\/jats:sup>\n                    Ga, and\n                    <jats:sup>99m<\/jats:sup>\n                    Tc, can be achieved at low temperatures (40\u00b0C), and for diagnostic imaging and radiotherapy applications. The combined strategy of extended x\u2010ray absorption fine structure spectroscopy (EXAFS), DFT calculations, and in vitro and in vivo radiostability experiments collectively confirmed that radiometal\u2010PID complexes exhibit ultra\u2010high radiostability.\n                    <jats:sup>177<\/jats:sup>\n                    Lu\u2010PID\u2010Ms were employed to accurately predict normal organ shunts and radiotherapy in rat and rabbit VX2 orthotopic live tumor models, demonstrating their ultra\u2010radiostability and remarkable anti\u2010tumor efficacy. Furthermore, Radiometals\u2010PID\u2010Ms have an adjustable shelf life, enabling on\u2010demand radiolabeling for drug preparation, achieving rapid \u2018on\u2010demand\u2019 capability. This innovative approach has the potential to inspire the synthesis of numerous coordination polymeric materials for various applications in PET\/SPECT\u2010mediated radiopharmaceutical therapy, alpha\u2010nucleophile\u2010targeted radiotherapy, and MRI contrast agents.\n                  <\/jats:p>","DOI":"10.1002\/advs.76278","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T19:44:28Z","timestamp":1782243868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultra\u2010Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal\u2010Labeling Platform for Cancer Radioembolization"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3474-0659","authenticated-orcid":false,"given":"Xiao","family":"Xu","sequence":"first","affiliation":[{"name":"Cancer Center Guangdong Engineering Research Center of Boron Neutron Therapy and Application in Malignant Tumors Dongguan Key Laboratory of Precision Diagnosis and Treatment for Tumors The Tenth Affiliated Hospital, Southern Medical University (Dongguan People\u2019s Hospital) Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenwen","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine Laboratory National Innovation Platform for Industry\u2010Education Integration in Vaccine Research School of Public Health Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Advanced Research Institute Chinese Academy of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Liu","sequence":"additional","affiliation":[{"name":"Cancer Center Guangdong Engineering Research Center of Boron Neutron Therapy and Application in Malignant Tumors Dongguan Key Laboratory of Precision Diagnosis and Treatment for Tumors The Tenth Affiliated Hospital, Southern Medical University (Dongguan People\u2019s Hospital) Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Liu","sequence":"additional","affiliation":[{"name":"Cancer Center Guangdong Engineering Research Center of Boron Neutron Therapy and Application in Malignant Tumors Dongguan Key Laboratory of Precision Diagnosis and Treatment for Tumors The Tenth Affiliated Hospital, Southern Medical University (Dongguan People\u2019s Hospital) Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Li","sequence":"additional","affiliation":[{"name":"Cancer Center Guangdong Engineering Research Center of Boron Neutron Therapy and Application in Malignant Tumors Dongguan Key Laboratory of Precision Diagnosis and Treatment for Tumors The Tenth Affiliated Hospital, Southern Medical University (Dongguan People\u2019s Hospital) Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichen","family":"Mao","sequence":"additional","affiliation":[{"name":"Cancer Center Guangdong Engineering Research Center of Boron Neutron Therapy and Application in Malignant Tumors Dongguan Key Laboratory of Precision Diagnosis and Treatment for Tumors The Tenth Affiliated Hospital, Southern Medical University (Dongguan People\u2019s Hospital) Dongguan China"},{"name":"Shanghai Applied Radiation Institute School of Environmental and Chemical Engineering Shanghai University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Xu","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Applied Physics Chinese Academy of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gan","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine Laboratory National Innovation Platform for Industry\u2010Education Integration in Vaccine Research School of Public Health Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine Laboratory National Innovation Platform for Industry\u2010Education Integration in Vaccine Research School of Public Health Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Shanghai Applied Radiation Institute School of Environmental and Chemical Engineering Shanghai University  Shanghai 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