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Immunogenic cell death (ICD) releases extracellular ATP, which can be rapidly converted into immunosuppressive adenosine. We therefore designed BSCS@PHY to synchronize ICD induction with local A2AR blockade in the same spatiotemporal window, aiming to protect antigen priming from adenosine\u2010mediated suppression. BSCS@PHY integrates a bismuth\u2013copper diselenide core for photothermal heating, glutathione depletion, and chemodynamic hydroxyl\u2010radical generation; hyaluronic\u2010acid\u2010modified phase\u2010change materials for on\u2010site activation; the A2AR antagonist SCH442416 for local A2AR blockade; and yeast cell wall (YCW) components for innate adjuvanticity. Thermography\u2010guided irradiation confines activation within a controlled window, melts the phase\u2010change shell to expose the catalytic surface, and coordinates ICD amplification with co\u2010localized A2AR blockade and dendritic\u2010cell activation. In 4T1 tumors, BSCS@PHY enables image\u2010guided activation, enhances ICD hallmarks, lowers adenosine signaling, promotes dendritic\u2010cell maturation and T\u2010cell priming, and improves tumor control, with additional benefit when combined with anti\u2010PD\u2010L1. Loss\u2010of\u2010function comparisons support nonredundant contributions of A2AR blockade and YCW\u2010mediated adjuvanticity. This material\u2010encoded strategy aligns danger\u2010signal generation with local A2AR blockade in the same tumor niche and offers a framework for pairing ICD induction with metabolic\u2010checkpoint control in cold tumors.<\/jats:p>","DOI":"10.1002\/advs.76303","type":"journal-article","created":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T11:57:16Z","timestamp":1782647836000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Material\u2010Encoded Synchronization of Immunogenic Cell Death With Adenosine A2A Receptor Blockade Reprograms the Tumor Microenvironment"],"prefix":"10.1002","volume":"13","author":[{"given":"Xiangting","family":"Yi","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs College of Pharmacy Jinan University  Guangzhou Guangdong P. 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