{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:06:08Z","timestamp":1790244368028,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"53","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471683"],"award-info":[{"award-number":["82471683"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971360"],"award-info":[{"award-number":["81971360"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2704001"],"award-info":[{"award-number":["2022YFC2704001"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFF0502900"],"award-info":[{"award-number":["2021YFF0502900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Endometriosis is a common gynecological disorder characterized by the ectopic growth of endometrium\u2010like tissue outside the uterine cavity and is associated with pelvic pain, infertility, and reduced quality of life. Although several theories have been proposed, the mechanisms by which endometrial cells disseminate and establish ectopic lesions remain incompletely understood. Here, we developed a dual\u2010color pseudo\u2010menstrual mouse model that enables real\u2010time in vivo tracking of circulating endometrial cells (CECs) while distinguishing their tissue origin as uterine\u2010derived or lesion\u2010derived. Using in vivo flow cytometry and two\u2010photon intravital microscopy, we found that both uterine\u2010derived and lesion\u2010derived CECs can enter the circulation and are detected at higher levels during menstruation\u2010like breakdown, potentially in association with local vascular remodeling as suggested by intravital imaging observations. These cells could localize to distant organs, including the lungs and other extrapelvic organs. In addition, both CEC populations exhibited three distinct daily peak periods, and CEC dynamics were significantly associated with fluctuations in serum prolactin levels. In conclusion, these findings provide in vivo support for hematogenous dissemination in endometriosis and suggest that hormonal rhythmicity may regulate CEC dynamics, with potential diagnostic and therapeutic implications.<\/jats:p>","DOI":"10.1002\/advs.76327","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T13:05:01Z","timestamp":1782479101000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010Time in Vivo Monitoring of Circulating Endometrial Cells: Uncovering Systemic Dissemination and Temporal Fluctuations in Endometriosis"],"prefix":"10.1002","volume":"13","author":[{"given":"Shang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University People's Hospital  Beijing China"},{"name":"Beijing Key Laboratory of Female Oncofertility  Beijing 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Beijing China"},{"name":"Peking University International Cancer Institute  Beijing China"},{"name":"Institute of Medical Technology and Cancer Hospital Peking University  Beijing China"},{"name":"Beijing Advanced Center of Cellular Homeostasis and Aging\u2010Related Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing) Peking University Cancer Hospital &amp; Institute  Beijing China"},{"name":"Biomedical Engineering Center Institute of Advanced Clinical Medicine Peking University  Beijing China"},{"name":"Peking University International Cancer Institute  Beijing China"},{"name":"Institute of Medical Technology and Cancer Hospital Peking University  Beijing China"},{"name":"Beijing Advanced Center of Cellular Homeostasis and Aging\u2010Related Diseases  Beijing 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University People's Hospital  Beijing China"},{"name":"Beijing Key Laboratory of Female Oncofertility  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University People's Hospital  Beijing China"},{"name":"Beijing Key Laboratory of Female Oncofertility  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing) Peking University Cancer Hospital &amp; Institute  Beijing China"},{"name":"Biomedical Engineering Center Institute of Advanced Clinical Medicine Peking University  Beijing China"},{"name":"Peking University International Cancer Institute  Beijing China"},{"name":"Institute of Medical Technology and Cancer Hospital Peking University  Beijing China"},{"name":"Beijing Advanced Center of Cellular Homeostasis and Aging\u2010Related Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyi","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University People's Hospital  Beijing China"},{"name":"Beijing Key Laboratory of Female Oncofertility  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunbin","family":"Wei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing) Peking University Cancer Hospital &amp; Institute  Beijing China"},{"name":"Biomedical Engineering Center Institute of Advanced Clinical Medicine Peking University  Beijing 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