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We focused on mechanosensitive hair cells (HCs), which are widely recognized as susceptible to aging. Using single\u2010cell RNA\u2010seq transcriptomic analysis of young and old mice, we show that old vestibular HCs exhibit conserved transcriptomic hallmarks of cellular aging, including cellular senescence, mitochondrial dysfunction, and impaired proteostasis, along with prominent cell type\u2010specific changes linked to hair bundle architecture and the mechanotransduction machinery. Consistent with these transcriptomic findings, imaging and electrophysiological recordings from old vestibular sensory epithelia reveal hair bundle degeneration and reduced mechanotransduction activity. Importantly, this structural and functional deterioration precedes HC loss, underscoring impaired hair bundle function as a key driver of ARVD. Furthermore, our comparative analysis identifies both shared and distinct aging signatures in vestibular and cochlear HCs, providing broader insight into the mechanisms that may underlie their different rates of age\u2010related degeneration.<\/jats:p>","DOI":"10.1002\/advs.76340","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:59:32Z","timestamp":1782478772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular and Cellular Hallmarks of Age\u2010Related Vestibular Hair Cell Degeneration"],"prefix":"10.1002","volume":"13","author":[{"given":"Samadhi","family":"Kulasooriya","sequence":"first","affiliation":[{"name":"Department of Biomedical Science School of Medicine Creighton University  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizhan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biomedical 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