{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:05:09Z","timestamp":1790244309890,"version":"4.1.0"},"reference-count":77,"publisher":"Wiley","issue":"53","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32560229"],"award-info":[{"award-number":["32560229"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52573277"],"award-info":[{"award-number":["52573277"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Diabetic keratopathy (DK) is a prevalent ocular surface complication of diabetes, frequently unnoticed until significant structural and functional deterioration occurs. Chronic hyperglycemic stress promotes inflammation in the corneal epithelial\u2010neural\u2010immune (epineuroimmune) unit, impeding tissue recovery and increasing infection susceptibility. To address this metabolic\u2013immune\u2013infection imbalance, we developed a light\u2010regulated biomimetic catalytic platform (WCN\n                    <jats:sub>x<\/jats:sub>\n                    \u2010Rh2) that integrates glucose degradation and monitoring, immune\u2010modulated epithelial\u2010neural regeneration, and antibacterial defense. This platform features an S\u2010scheme heterojunction (WCN\n                    <jats:sub>x<\/jats:sub>\n                    ) composed of graphitic carbon nitride and tungsten oxide, enabling visible\u2010light (VIS)\u2010driven glucose degradation, dark\u2010state colorimetric detection, and near\u2010infrared (NIR) photothermal antibacterial activity. Complementarily, the loaded ginsenoside Rh2\u2014identified via systematic screening\u2014inhibits the Nucleotide\u2010binding and oligomerization domain (NOD)\u2010like receptor signaling pathway. The combined action of WCN\n                    <jats:sub>x<\/jats:sub>\n                    and Rh2 reduces advanced glycation end products (AGEs), reactive oxygen species (ROS), and inflammatory signaling, reprogramming dendritic cell function to restore epineuroimmune homeostasis and drive tissue repair. These functions were validated in two animal models. In diabetic mice, VIS\u2010irradiated WCN\n                    <jats:sub>x<\/jats:sub>\n                    \u2010Rh2 accelerated corneal epithelial and nerve recovery. In a diabetic keratitis model, NIR\u2010activated WCN\n                    <jats:sub>x<\/jats:sub>\n                    \u2010Rh2 enabled effective corneal bacterial eradication and tissue repair. Overall, this work establishes a light\u2010driven metabolic\u2010modulation biomimetic paradigm and proposes an integrated strategy for managing DK.\n                  <\/jats:p>","DOI":"10.1002\/advs.76349","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T14:20:19Z","timestamp":1782915619000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Plant Photoregulator\u2010Inspired S\u2010Type Heterojunction System for Diabetic Keratopathy via Tri\u2010Modal Light\u2010Driven Immunometabolic Reprogramming, Tissue Repair, and Antibacterial Activity"],"prefix":"10.1002","volume":"13","author":[{"given":"Mengzhen","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Nanchang University  Nanchang Jiangxi P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"180","article-title":"Diabetic Keratopathy","volume":"79","author":"Schultz R. 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