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However, wavelength\u2010dependent optical fluence changes within tissue, i.e., spectral coloring, have impeded the development of photoacoustic oximetry. We present the arterial prior method (APM+; + denotes intravascular fluence correction), which leverages the high arterial sO\n                    <jats:sub>2<\/jats:sub>\n                    to locally calibrate the optical fluence within tissue to circumvent spectral coloring and reliably estimate the sO\n                    <jats:sub>2<\/jats:sub>\n                    near the artery. In phantom experiments with ex vivo animal tissue, APM+ resulted in a median estimation error of 2.9% compared to 9.8% from the traditional linear unmixing method (LUM). In human imaging experiments of the radial artery\u2010vein pair in eight healthy adult volunteers, the estimated venous sO\n                    <jats:sub>2<\/jats:sub>\n                    s from APM+ (median: 72.3%, interquartile range\/IQR: 8.9%) were concentrated around the typical 60%\u201380% range in healthy individuals, whereas those from LUM (median: 75.2%, IQR: 34.4%) varied widely. When imaging the wrists of the eight subjects through ex vivo animal tissue of thicknesses up to 1.5\u00a0cm, APM+ provided more consistent estimates than LUM, indicating its robustness with depth.\n                  <\/jats:p>","DOI":"10.1002\/advs.76366","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T11:59:01Z","timestamp":1783079941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Arterial Blood\u2010Mediated Deep\u2010Tissue Photoacoustic Oximetry"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7659-4878","authenticated-orcid":false,"given":"Karteekeya","family":"Sastry","sequence":"first","affiliation":[{"name":"Caltech Optical Imaging Laboratory Andrew and Peggy Cherng Department of Medical Engineering Department of Electrical Engineering California Institute of Technology  Pasadena California 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6124-7230","authenticated-orcid":false,"given":"Jigmi","family":"Basumatary","sequence":"additional","affiliation":[{"name":"Caltech Optical Imaging Laboratory Andrew and Peggy Cherng Department of Medical Engineering Department of Electrical Engineering California Institute of Technology  Pasadena California USA"},{"name":"Department of Biosciences and Bioengineering Indian Institute of Technology Jammu  Jammu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Caltech Optical Imaging Laboratory Andrew and Peggy Cherng Department of Medical Engineering Department of Electrical Engineering California Institute of Technology  Pasadena California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong V.","family":"Wang","sequence":"additional","affiliation":[{"name":"Caltech 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