{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:06:44Z","timestamp":1790244404031,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"53","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Colon cancer remains a formidable therapeutic challenge due to its high malignancy and limited treatment options. To overcome this, we develop a multifunctional nanoplatform (HILA) using hollow mesoporous manganese dioxide (HMnO\n                    <jats:sub>2<\/jats:sub>\n                    ) to co\u2010load lactate oxidase (LOX) and the photosensitizer indocyanine green (ICG), coated with hyaluronic acid (HA) for targeted delivery to CD44\u2010overexpressing tumor cells. Within the tumor microenvironment (TME), LOX converts lactate to more acidic pyruvate and H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , which subsequently react with HMnO\n                    <jats:sub>2<\/jats:sub>\n                    to produce O\n                    <jats:sub>2<\/jats:sub>\n                    , establishing a self\u2010sustaining HMnO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010LOX catalytic cycle that continuously depletes lactate (inducing tumor starvation) while alleviating hypoxia. The acidic pyruvate accelerates HMnO\n                    <jats:sub>2<\/jats:sub>\n                    degradation, releasing ICG and Mn\n                    <jats:sup>2+<\/jats:sup>\n                    ions. Under near\u2010infrared irradiation, the generated O\n                    <jats:sub>2<\/jats:sub>\n                    facilitates photodynamic\/photothermal therapy (PDT\/PTT) of ICG, while Mn\n                    <jats:sup>2+<\/jats:sup>\n                    catalyzes H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    to generate hydroxyl radicals (\u2022OH) for enhanced chemodynamic therapy (CDT). Crucially, the coordinated TME remodeling, (featuring lactate exhaustion, pH reduction, and O\n                    <jats:sub>2<\/jats:sub>\n                    \/H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    accumulation) creates a positive feedback loop that fuels PDT\/PTT\/CDT\/starvation therapy. This self\u2010reinforcing cycle integrates PDT\/PTT\/CDT\/starvation therapy, demonstrating potent tumor suppression in vivo and offering a paradigm for metabolic modulation\u2010synergized oncotherapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.76367","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:33:36Z","timestamp":1782477216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Self\u2010Sustaining Lactate Depletion Nanoplatform Remodels Tumor Microenvironment and Augments Synergistic Photodynamic\/Photothermal\/Chemodynamic\/Starvation Therapy for Eradication of Colon Cancer"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1772-7698","authenticated-orcid":false,"given":"Yu\u2010E.","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine &amp; School of Pharmaceutical Sciences Guizhou International Science &amp; Technology Cooperation Base for Druggability Research of Natural Medicines The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province the Key Laboratory of Optimal Utilization of Natural Medicine Resources Guizhou Medical University  Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibo","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine &amp; School of Pharmaceutical Sciences Guizhou International Science &amp; Technology Cooperation Base for Druggability Research of Natural Medicines The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province the Key Laboratory of Optimal Utilization of Natural Medicine Resources Guizhou Medical University  Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenying","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine &amp; School of Pharmaceutical Sciences Guizhou International Science &amp; Technology Cooperation Base for Druggability Research of Natural Medicines The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province the Key Laboratory of Optimal Utilization of Natural Medicine Resources Guizhou Medical University  Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Duan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine &amp; School of Pharmaceutical Sciences Guizhou International Science &amp; Technology Cooperation Base for Druggability Research of Natural Medicines The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province the Key Laboratory of Optimal Utilization of Natural Medicine Resources Guizhou Medical University  Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine &amp; School of Pharmaceutical Sciences Guizhou International Science &amp; Technology Cooperation Base for Druggability Research of Natural Medicines The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province the Key Laboratory of Optimal Utilization of Natural Medicine Resources Guizhou Medical University  Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Zeng","sequence":"additional","affiliation":[{"name":"School of Biology and Engineering Guizhou Medical University  Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Hong","sequence":"additional","affiliation":[{"name":"School of Biology and Engineering Guizhou Medical University  Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Novel Anti\u2010Cancer Drug Targets Discovery and Application School of Pharmaceutical Sciences Guizhou Medical University  Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Tao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine &amp; School of Pharmaceutical Sciences Guizhou International Science &amp; Technology Cooperation Base for Druggability Research of Natural Medicines The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province the Key Laboratory of Optimal Utilization of Natural Medicine Resources Guizhou Medical University  Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewu","family":"Zeng","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Natural and Biomimetic Drugs Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoda","family":"Xiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine &amp; School of Pharmaceutical Sciences Guizhou International Science &amp; Technology Cooperation Base for Druggability Research of Natural Medicines The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province the Key Laboratory of Optimal Utilization of Natural Medicine Resources Guizhou Medical University  Guizhou 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