{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:05:53Z","timestamp":1790244353861,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"53","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52302350"],"award-info":[{"award-number":["52302350"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024QC370"],"award-info":[{"award-number":["ZR2024QC370"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024MB043"],"award-info":[{"award-number":["ZR2024MB043"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cuproptosis, a copper\u2010dependent form of regulated cell death, holds significant promise for oncology, but its therapeutic utility is constrained by the inefficient intratumoral generation of the bioactive Cu\n                    <jats:sup>+<\/jats:sup>\n                    species. To this end, we report a NIR\u2010II light\u2010activatable thermoelectric nanoreactor (Te@PDA\u2010Cu\n                    <jats:sup>II<\/jats:sup>\n                    ) designed to achieve spatiotemporally controlled Cu\n                    <jats:sup>+<\/jats:sup>\n                    production for enhanced cancer therapy. The nanoreactor comprises a tellurium nanorod core, which exhibits a strong thermoelectric effect under 1064\u00a0nm light irradiation, coated with a polydopamine (PDA) layer that serves both as a Cu\n                    <jats:sup>2+<\/jats:sup>\n                    chelation scaffold and an electron\u2010conducting interface. Photothermal activation generates a directional electron flow from the Te core, which is efficiently relayed through the PDA layer to reduce surface\u2010bound Cu\n                    <jats:sup>2+<\/jats:sup>\n                    to Cu\n                    <jats:sup>+<\/jats:sup>\n                    . Such in situ valence conversion potently triggers cuproptosis via dihydrolipoamide S\u2010acetyltransferase (DLAT) aggregation and Fe\u2500S cluster destabilization. The ensuing cuproptosis initiates immunogenic cell death (ICD), promoting dendritic cell maturation and cytotoxic T lymphocyte infiltration. In orthotopic and metastatic breast cancer models, this thermoelectric\u2010immunological cascade not only eradicates primary tumors but also synergizes with aPD\u20101 checkpoint blockade to suppress distant metastases and establish durable immune memory. This work establishes a physical energy\u2010driven strategy for precise cuproptosis activation and demonstrates its potential to amplify cancer immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.76368","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:21:44Z","timestamp":1782858104000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["NIR\u2010II Light\u2010Triggered Electron Flow Initiates Cuproptosis\u2010Centered Thermoelectric\u2010Immunotherapy for Breast Cancer"],"prefix":"10.1002","volume":"13","author":[{"given":"Boyu","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, Shandong Key Laboratory of Digital Diagnosis and Treatment of Thoracic Oncology The First Affiliated Hospital of Shandong First Medical University &amp; Shandong Provincial Qianfoshan Hospital  Jinan Shandong P. R. China"},{"name":"Science and Technology Innovation Center Shandong First Medical University &amp; Shandong Academy of Medicine Sciences  Jinan Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Fan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) &amp; Institute of Advanced Materials (IAM) Nanjing University of Posts &amp; Telecommunications  Nanjing Jiangsu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shushu","family":"Chu","sequence":"additional","affiliation":[{"name":"Science and Technology Innovation Center Shandong First Medical University &amp; Shandong Academy of Medicine Sciences  Jinan Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shining","family":"Yang","sequence":"additional","affiliation":[{"name":"Science and Technology Innovation Center Shandong First Medical University &amp; Shandong Academy of Medicine Sciences  Jinan Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuechao","family":"Yang","sequence":"additional","affiliation":[{"name":"Science and Technology Innovation Center Shandong First Medical University &amp; Shandong Academy of Medicine Sciences  Jinan Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Faculty of Light Industry, State Key Laboratory of Green Papermaking and Resource Recycling Qilu University of Technology (Shandong Academy of Sciences)  Jinan P. R. 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