{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:29:04Z","timestamp":1792808944275,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"54","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52473317"],"award-info":[{"award-number":["52473317"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["T2321005"],"award-info":[{"award-number":["T2321005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32530060"],"award-info":[{"award-number":["32530060"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012462","name":"Collaborative Innovation Center of Suzhou Nano Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012462","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Mucosa, a vital interface between the body and external environment, often suffers from reactive oxygen burden within its microenvironment, leading to various mucosal inflammatory diseases. Drug delivery directly to inflamed mucosal regions offers a promising therapeutic approach, yet efficacy is compromised by inherent physiological clearance mechanisms. Herein, we developed a covalent mucoadhesive nanoantioxidant self\u2010assembled by a cysteine\u2010modified short peptide (CR\n                    <jats:sub>8<\/jats:sub>\n                    L\n                    <jats:sub>10<\/jats:sub>\n                    ) and catalase (CAT) for the treatment of mucosal inflammatory diseases. The obtained CR\n                    <jats:sub>8<\/jats:sub>\n                    L\n                    <jats:sub>10<\/jats:sub>\n                    @CAT nanocomplexes with a cysteine\u2010decorated surface enable robust mucoadhesion by forming dynamic disulfide bonds with mucin\u2010rich mucosa, leading to significantly enhanced CAT retention. Upon intravesical instillation, CR\n                    <jats:sub>8<\/jats:sub>\n                    L\n                    <jats:sub>10<\/jats:sub>\n                    @CAT with improved urine\u2010resistant bladder retention, could be used to treat hard\u2010to\u2010manage interstitial cystitis\/bladder pain syndrome (IC\/BPS). Notably, intravesically administered CR\n                    <jats:sub>8<\/jats:sub>\n                    L\n                    <jats:sub>10<\/jats:sub>\n                    @CAT effectively eliminated excessive reactive oxygen species (ROS) in the bladder mucosa, thereby inhibiting pro\u2010inflammatory responses, restoring urothelial integrity, and alleviating pain and voiding dysfunction, demonstrating significantly better analgesic effects and superior functional improvement than clinically used intravesical agents. Additionally, inhalation of the mucoadhesive CR\n                    <jats:sub>8<\/jats:sub>\n                    L\n                    <jats:sub>10<\/jats:sub>\n                    @CAT nanoantioxidant also showed enhanced pulmonary retention to effectively mitigate ROS\u2010associated inflammation in treating acute lung injury (ALI). This mucoadhesive CR\n                    <jats:sub>8<\/jats:sub>\n                    L\n                    <jats:sub>10<\/jats:sub>\n                    @CAT nanoantioxidant represents an effective therapeutic strategy to manage different mucosal inflammatory diseases, holding great promise for clinical translation.\n                  <\/jats:p>","DOI":"10.1002\/advs.76390","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T09:21:52Z","timestamp":1782984112000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mucoadhesive Peptide\u2010Catalase Self\u2010Assembled Nano\u2010Formulation for Effective Treatment of Mucosal Inflammatory Diseases"],"prefix":"10.1002","volume":"13","author":[{"given":"Xinzhu","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Functional Nano &amp; Soft Materials (FUNSOM) Soochow University Suzhou Jiangsu 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