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Here we report that mechanochemically generated organocalcium species exhibit an unusual chemoselectivity toward carboxylate salts, enabling the direct and selective transformation of carboxylates into ketones without overaddition, a persistent limitation of conventional organometallic chemistry. Commercially available calcium metal is directly activated by ball milling with aryl iodides to generate reactive organocalcium intermediates under solvent\u2010minimized and ambient conditions. This protocol exhibits broad substrate scope, excellent chemoselectivity, and high functional\u2010group tolerance. Moreover, the reaction can be extended to the direct use of carboxylic acids, enabling a one\u2010step synthesis of pharmaceutically and industrially relevant ketones.<\/jats:p>","DOI":"10.1002\/advs.76440","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:16:15Z","timestamp":1783606575000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Calcium\u2010Mechanochemistry Enabled Ketone Synthesis From Organic Iodides and Carboxylic Acids"],"prefix":"10.1002","volume":"13","author":[{"given":"Mengyao","family":"Pei","sequence":"first","affiliation":[{"name":"School of Pharmacy Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5261-0254","authenticated-orcid":false,"given":"Zekun","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Pharmacy 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