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Herein, we develop an efficient detection platform based on Au nanoparticles decorated mesoporous Cr\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    (Au@mCr\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    ) particles with a single primitive continuous structure (i.e., Schwarz P surface) as the matrix. Owing to the low\u2010tortuosity mesoporous pathways and customized chemical composition, the Au@mCr\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    exhibits high\u2010efficiency light absorption and electron transfer, showing great potential for sensitive, reproducible, and selective metabolite detection. Therefore, it is considered as a high\u2010performance and reliable matrix material for metabolic biomarkers screening. As a proof of concept, the Au@mCr\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    \u2010based detection platform decodes the saliva metabolic fingerprints. With the assistance of machine learning, the platform achieves high diagnostic performance for periodontitis, with the areas under the curve of 0.875\u20130.934. Furthermore, a simplified biomarker panel is established, which provides a deeper mechanism understanding of the metabolic alternation of periodontitis and offers new insights into its diagnosis and pathogenesis.\n                  <\/jats:p>","DOI":"10.1002\/advs.76441","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T12:17:42Z","timestamp":1785154662000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An Efficient Detection Platform Based on Mesoporous Au@Cr\n                    <sub>2<\/sub>\n                    O\n                    <sub>3<\/sub>\n                    Particles with Schwarz P Surface for Precise Periodontitis Metabolite Profiling"],"prefix":"10.1002","volume":"13","author":[{"given":"Yue","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Chemistry Shanghai Stomatological Hospital &amp; School of Stomatology State Key Laboratory of Coatings for Advanced Equipment Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan University  Shanghai P. 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