{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:55:10Z","timestamp":1790603710449,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"54","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404198"],"award-info":[{"award-number":["82404198"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173457"],"award-info":[{"award-number":["82173457"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Radiation\u2010induced lung injury (RILI) is a major complication of nuclear radiation exposure and thoracic radiotherapy, driven in part by a vicious cycle of oxidative stress and mitochondrial dysfunction. Peroxisome proliferator\u2010activated receptor gamma (PPAR\u2010\u03b3), a key regulator of mitochondrial homeostasis and inflammatory resolution, therefore represents a potential therapeutic target, yet multi\u2010omics analyses revealed that this immunometabolic checkpoint remains functionally constrained in irradiated macrophages. To reactivate this pathway, we developed an inhalable, ROS\u2010responsive nanospray (HANP) by loading nicotinamide adenine dinucleotide (NAD\n                    <jats:sup>+<\/jats:sup>\n                    ) and astaxanthin (ASX) into a hollow mesoporous polydopamine (HMPDA) shell. Excess ROS in microenvironment triggers oxidative degradation of the HMPDA shell, enabling intracellular release of NAD\n                    <jats:sup>+<\/jats:sup>\n                    and ASX. Mechanistically, NAD\n                    <jats:sup>+<\/jats:sup>\n                    promotes SIRT1\u2010mediated deacetylation of PPAR\u2010\u03b3, whereas ASX serves as an activating ligand, thereby cooperatively restoring PPAR\u2010\u03b3 signaling. This response re\u2010establishes macrophage mitochondrial homeostasis by coordinating mitochondrial biogenesis and mitophagy, which subsequently promotes a shift toward a reparative macrophage phenotype. In murine models of focal thoracic irradiation and lethal whole\u2010body irradiation, HANP markedly attenuated lung injury and improved survival. Collectively, these findings identify macrophage PPAR\u2010\u03b3 as a therapeutically actionable redox\u2010immunometabolic regulator and support inhaled dual\u2010activation of this pathway as a promising strategy for protection against RILI in both clinical and emergency settings.\n                  <\/jats:p>","DOI":"10.1002\/advs.76447","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T12:30:03Z","timestamp":1783513803000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inhalable ROS\u2010Responsive Nanospray Activates PPAR\u2010\u03b3 to Restore Macrophage Mitochondrial Homeostasis and Attenuate Radiation\u2010Induced Lung Injury"],"prefix":"10.1002","volume":"13","author":[{"given":"Mingquan","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Military Preventive Medicine Institute of Combined Injury State Key Laboratory of Trauma and Chemical Poisoning Chongqing Engineering Research Center for Nanomedicine Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Military Preventive Medicine Institute of Combined Injury State Key Laboratory of Trauma and Chemical Poisoning Chongqing Engineering Research Center for Nanomedicine Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqian","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Military Preventive Medicine Institute of Combined Injury State Key Laboratory of Trauma and Chemical Poisoning Chongqing Engineering Research Center for Nanomedicine Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyao","family":"Tan","sequence":"additional","affiliation":[{"name":"Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xie","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Military Preventive Medicine Institute of Combined Injury State Key Laboratory of Trauma and Chemical Poisoning Chongqing Engineering Research Center for Nanomedicine Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaizhi","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Military Preventive Medicine Institute of Combined Injury State Key Laboratory of Trauma and Chemical Poisoning Chongqing Engineering Research Center for Nanomedicine Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Military Preventive Medicine Institute of Combined Injury State Key Laboratory of Trauma and Chemical Poisoning Chongqing Engineering Research Center for Nanomedicine Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Military Preventive Medicine Institute of Combined Injury State Key Laboratory of Trauma and Chemical Poisoning Chongqing Engineering Research Center for Nanomedicine Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximei","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Radiation Oncology Key Laboratory of Sichuan Province Sichuan Clinical Research Center for Cancer Sichuan Cancer Hospital &amp; Institute Affiliated Cancer Hospital of University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2980-4550","authenticated-orcid":false,"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Military Preventive Medicine Institute of Combined Injury State Key Laboratory of Trauma and Chemical Poisoning Chongqing Engineering Research Center for Nanomedicine Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0804-9891","authenticated-orcid":false,"given":"Shenglin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Military Preventive Medicine Institute of Combined Injury State Key Laboratory of Trauma and Chemical Poisoning Chongqing Engineering Research Center for Nanomedicine Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.03.033"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201042171\u2010z"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.03.047"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.120628"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202401394"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121103"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43556\u2010025\u201000358\u20104"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abq0615"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.05.006"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.08.010"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658\u2010025\u201000750\u20106"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3600"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI170501"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010020\u201000859\u20100"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20220115"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c07135"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018\u2010025\u201000905\u20106"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202417920"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2023.08.006"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2023.108391"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rraa062"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2015.11.005"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aao0303"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450118666170622091333"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70045"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2022.05.005"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13976"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(25)00515\u20107"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2026.104091"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201038134\u2010z"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.136740"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000001215"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010024\u201001208\u2010z"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00411\u2010011\u20100390\u20109"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.129122"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3005"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061738"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03988"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640616640443"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.11.018"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450119666180131105158"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.54803"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202101033"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010026\u201004030\u2010z"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010022\u201000886\u20103"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07813"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq609"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.027"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305363"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121937"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/md17040242"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010022\u201001307\u2010x"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010025\u201002262\u20103"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.123004"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418\u2010023\u201001230\u20100"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2022.01.030"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.09.010"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104809"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70363"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594\u2010023\u201001156\u20108"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400407a"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.12.028"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.76447","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.76447","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.76447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:58:56Z","timestamp":1790600336000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.76447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,8]]},"references-count":62,"journal-issue":{"issue":"54","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/advs.76447"],"URL":"https:\/\/doi.org\/10.1002\/advs.76447","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,8]]},"assertion":[{"value":"2026-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e76447"}}