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Herein, we report a Pd\u2010catalyzed asymmetric dearomative Heck\/Tsuji\u2010Trost reaction, which achieves the 1,4\u2010difunctionalization of the non\u2010activated naphthalenes for the synthesis of a series of spirocyclic products bearing two distal chiral centers. Through the employment of the new chiral sulfinamide phosphine ligand featuring bulky steric hindrance, the reaction system exhibits excellent regio\u2010, enantio\u2010, and diastereoselectivity. 4\u2010Aminospirocyclohexene oxindoles with diverse functional groups were obtained in moderate to excellent yields with good to excellent enantioselectivity. The reaction proceeds under mild conditions with versatile transformations of the products. Moreover, a plausible reaction mechanism was proposed based on the mechanistic studies.<\/jats:p>","DOI":"10.1002\/advs.76459","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:27:32Z","timestamp":1783945652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pd\u2010Catalyzed Asymmetric Dearomative Heck\/Tsuji\u2010Trost Difunctionalization of Naphthalenes"],"prefix":"10.1002","volume":"13","author":[{"given":"Long\u2010Ling","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Chemistry, State Key Laboratory of Green Chemical Synthesis and Conversion Fudan University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, State Key Laboratory of Green Chemical Synthesis and Conversion Fudan University  Shanghai P. R. 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