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Inspired by native tissue hierarchical gradients and endogenous healing mechanisms, we developed an electric field\u2010driven continuous gradient hydrogel (GHZF4) via spatiotemporal programming. Integrating nanofiber\u2010reinforced self\u2010adaptive matrix, electric field\u2010induced nanofiber alignment, and ZIF\u20108 nanocarrier\u2010mediated bioactive release, GHZF4 constructs compositional\/structural\/mechanical gradients. Its bone\u2010mimetic zone achieves burst release of PDGF\u2010BB and sustained release of BMP\u20102 for vascularized osteogenesis, while the cartilage\u2010mimetic zone sustains TGF\u2010\u03b23 release for chondrogenesis. In vitro, GHZF4 enhances macrophage M2 polarization, autologous stem cell recruitment, angiogenesis, and osteochondral differentiation. In rat\/rabbit defect models, it enables seamless integration and functional repair, validated by micro\u2010CT, nanoindentation and histology. 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