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Here, we report a disulfide\u2011sticker strategy in the recombinant scallop adhesive protein Sbp9\n                    <jats:sup>\u0394<\/jats:sup>\n                    . Dynamic disulfide bonds, acting synergistically with Ca\n                    <jats:sup>2+<\/jats:sup>\n                    coordination, orchestrate the multiscale hierarchical self\u2010assembly of Sbp9\n                    <jats:sup>\u0394<\/jats:sup>\n                    by modulating its conformational heterogeneity. Spectroscopic and scattering analyses reveal that disulfide formation acts as a covalent sticker, rigidifying Sbp9\n                    <jats:sup>\u0394<\/jats:sup>\n                    into \u03b2\u2010sheet\u2010rich rod\u2010like nanostructures, which direct orderly aggregation into extensive two\u2010dimensional networks. The resulting coating exhibits robust wet adhesion across diverse substrates, accompanied by intrinsic antioxidant activity. As a proof of concept, the biocompatible Sbp9\n                    <jats:sup>\u0394<\/jats:sup>\n                    coating markedly promotes hair regeneration by enhancing angiogenesis, stimulating follicular cell proliferation, and effectively scavenging reactive oxygen species (ROS), exhibiting superior efficacy compared with minoxidil. In a mouse model of androgenetic alopecia, the Sbp9\n                    <jats:sup>\u0394<\/jats:sup>\n                    coating activates the follicular niche through the upregulation of Wnt signaling and the downregulation of calcium signaling, leading to robust hair follicle activation. By integrating insights from marine biology, biophysics, and materials science, this work elucidates a disulfide\u2010mediated assembly paradigm in marine adhesives and translates it into a functional strategy for hair regeneration.\n                  <\/jats:p>","DOI":"10.1002\/advs.76497","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:58:19Z","timestamp":1783605499000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Disulfide\u2010Sticker Strategy for Marine Adhesive Coatings: From Deciphering Self\u2010Assembly Mechanism to Functional Application in Hair Regeneration"],"prefix":"10.1002","volume":"13","author":[{"given":"Lulu","family":"Wang","sequence":"first","affiliation":[{"name":"Fang Zongxi Center for Marine Evo\u2010Devo, MoE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences Ocean University of China  Qingdao China"},{"name":"Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory For Marine Science and Technology  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Yang","sequence":"additional","affiliation":[{"name":"Fang Zongxi Center for Marine Evo\u2010Devo, MoE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences Ocean University of China  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Physics City University of Hong Kong  Hong Kong China"},{"name":"Shenzhen Research Institute City University of Hong Kong  Shenzhen China"},{"name":"Neutron Science Platform Songshan Lake Materials Laboratory  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanghui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Fang Zongxi Center for Marine Evo\u2010Devo, MoE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences Ocean University of China  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Wei","sequence":"additional","affiliation":[{"name":"Fang Zongxi Center for Marine Evo\u2010Devo, MoE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences Ocean University of China  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"National Facility for Protein Science Shanghai Chinese Academy of Sciences (CAS)  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangqiang","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Physics City University of Hong Kong  Hong Kong China"},{"name":"Shenzhen Research Institute City University of Hong Kong  Shenzhen 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