{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:00:00Z","timestamp":1791198000092,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"55","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lyotropic liquid crystalline nanoparticles (LCNPs), including cubosomes, are increasingly investigated as antimicrobial nanomaterials because non\u2010lamellar lipid nanoparticles can fuse with biological membranes, exchange lipids, and improve antimicrobial delivery or antibiotic combination treatment. However, prior studies have mainly addressed fusion, uptake, encapsulation, or payload stabilization, rather than testing whether retained internal curvature can be isolated as a design variable for antibacterial potentiation in a matched LCNP series. Herein, we generated lamellar vesicles, primitive cubosomes (P\u2010cubosomes,\n                    <jats:italic>Im3m<\/jats:italic>\n                    ), and diamond cubosomes (D\u2010cubosomes,\n                    <jats:italic>Pn3m<\/jats:italic>\n                    ) from the same phytantriol\/DPPS lipid system. When combined with free daptomycin, rather than being used as drug\u2010loaded carriers, these LCNPs exhibited curvature\u2010dependent potentiation hierarchy against methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA), vesicles &lt; P\u2010cubosomes &lt; D\u2010cubosomes. Fluorescence imaging, electron microscopy, and neutron reflectometry showed progressively stronger membrane association, lipid extraction, and bilayer disruption with increasingly negative curvature. In a murine bacteremia model using a sub\u2010optimal daptomycin regimen, the same curvature\u2010dependent efficacy trend was retained in vivo, providing proof\u2010of\u2010concept support rather than therapeutic validation. This study provides direct experimental evidence, in a matched antibacterial LCNP system, that retained internal curvature modulates membrane remodeling and potentiates daptomycin against MRSA.\n                  <\/jats:p>","DOI":"10.1002\/advs.76516","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:22:54Z","timestamp":1783606974000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhanced Antibacterial Properties of Lyotropic Liquid Crystalline Nanoparticles via Curvature Modulation"],"prefix":"10.1002","volume":"13","author":[{"given":"Xiangfeng","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Materials Science and Engineering Faculty of Engineering Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Faculty of Engineering Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9306-9709","authenticated-orcid":false,"given":"Chenguang","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Kidney Transplantation Nephropathy Hospital The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi P. R. China"},{"name":"Institute of Organ Transplantation Xi'an Jiaotong University  Xi'an P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xenia","family":"Kostoulias","sequence":"additional","affiliation":[{"name":"Infection and Immunity Program Monash Biomedicine Discovery Institute and Department of Microbiology Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2431-6985","authenticated-orcid":false,"given":"Anton P. Le","family":"Brun","sequence":"additional","affiliation":[{"name":"Australian Centre for Neutron Scattering Australian Nuclear Science and Technology Organisation  Kirrawee DC New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsien\u2010Yi","family":"Hsu","sequence":"additional","affiliation":[{"name":"School of Energy and Environment &amp; Department of Materials Science and Engineering &amp; Centre for Functional Photonics (CFP) City University of Hong Kong  Kowloon Tong Hong Kong P. R. China"},{"name":"Shenzhen Research Institute of City University of Hong Kong  Shenzhen P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhih\u2010Hang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Infection and Immunity Program Monash Biomedicine Discovery Institute and Department of Microbiology Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chemistry &amp; Materials Engineering Wenzhou University  Wenzhou Zhejiang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Strugnell","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton Y.","family":"Peleg","sequence":"additional","affiliation":[{"name":"Infection and Immunity Program Monash Biomedicine Discovery Institute and Department of Microbiology Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin\u2010Hui","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Faculty of Engineering Monash University  Melbourne Victoria Australia"},{"name":"Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology Monash University  Melbourne Victoria 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