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However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models. While human\u2010derived neural circuits offer therapeutic promise, generating high\u2010purity, functionally mature spiral ganglion neurons (SGNs) and achieving their oriented integration remain substantial challenges. In this study, we successfully differentiated human induced pluripotent stem cells (hiPSCs) into SGN\u2010like neurons that closely resemble in vivo counterparts. Using electrically conductive biomimetic scaffolds with highly ordered topological structures promoted SGN\u2010like neurons maturation, growth orientation. Furthermore, by co\u2010culturing SGN\u2010like neurons with denervated cochlear tissues, we established a human\u2010derived in vitro model capable of mimicking the auditory neural circuit. We efficiently recapitulated an in vitro auditory neural circuit on biomimetic scaffolds, elucidated transcriptional changes underlying SGN\u2010like neurons' maturation, and reproduced the protective phenotypes against cisplatin\u2010induced auditory circuit damage. These results demonstrate that the constructed human\u2010derived in vitro neural circuit model is a reliable platform for drug screening with broad application prospects.<\/jats:p>","DOI":"10.1002\/advs.76525","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T21:01:16Z","timestamp":1783803676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functionalized Biomimetic Scaffolds for Human\u2010Derived Auditory Neural Circuit Construction"],"prefix":"10.1002","author":[{"given":"Pan","family":"Feng","sequence":"first","affiliation":[{"name":"Spine Surgery Department Nantong First People's Hospital State Key Laboratory of Digital Medical Engineering Jiangsu Provincial Key Laboratory of Critical Care Medicine School of Life Sciences and Technology School of Medicine Advanced Institute for Life and Health Southeast University  Nanjing 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