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Using a streptozotocin\u2010induced insulin\u2010deficient, type 1 diabetes\u2010like DCM mouse model, we show that intermittent fasting (IF) improves cardiac function and attenuates myocardial remodeling. Antibiotic\u2010mediated microbiota depletion largely abolished these benefits, whereas fecal microbiota transplantation from IF\u2010treated donors recapitulated cardioprotection, supporting a causal role of the gut microbiota. Metagenomic profiling identified\n                    <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                    (\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    ) as a prominent IF\u2010responsive taxon, and\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    supplementation alleviated cardiac injury without obvious improvement in glycaemia. Integrated serum and heart metabolomics identified 1\u2010methyl\u2010L\u2010histidine as a microbiota\u2010associated metabolite reduced in diabetes but restored by IF and\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    . In vitro and ex vivo assays further supported an L\u2010anserine\u2010linked microbial route for 1\u2010methyl\u2010L\u2010histidine generation. Importantly, oral 1\u2010methyl\u2010L\u2010histidine supplementation recapitulated key cardioprotective effects, remodeled cardiac lipid homeostasis, and reduced lipid peroxidation and oxidative injury. Together, these findings support a gut microbiota\u2013metabolite\u2013lipid axis associated with IF\u2010related cardioprotection in DCM and highlight microbial metabolites as tractable targets to complement dietary intervention.\n                  <\/jats:p>","DOI":"10.1002\/advs.76528","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:57:27Z","timestamp":1783691847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With\n                    <i>Akkermansia Muciniphila<\/i>\n                    and 1\u2010methyl\u2010L\u2010histidine"],"prefix":"10.1002","volume":"13","author":[{"given":"Kaiyuan","family":"Jiang","sequence":"first","affiliation":[{"name":"Institute of Metabonomics &amp; Medical NMR School of Pharmaceutical Sciences Wenzhou Medical University  Wenzhou 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