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Here, we identify aberrant STING activation as a key driver of microglial pyroptosis and post\u2010SAH injury. Transcriptomic and biochemical analyses support a close association between STING signaling and microglial pyroptosis, with MAPK signaling acting as a functionally relevant downstream pathway. Based on this mechanistic insight, we engineered MG1 peptide\u2010functionalized, neutrophil membrane\u2010coated STING\u2010PROTAC nanoparticles (MG1@NM\u2010Px) to enable blood\u2010brain barrier penetration, microglia\u2010targeted delivery, and efficient STING degradation in vivo. This catalytic degradation suppressed the inflammasome\u2010related activation and GSDME\u2010associated pyroptotic signaling, reduced pro\u2010inflammatory cytokine secretion, and prevented neuronal apoptosis. Histopathological examination showed preserved Nissl body integrity, while behavioral testing revealed significant improvements in neurological function. Collectively, this engineered neutrophil membrane\u2010coated STING\u2010PROTAC nanoplatform effectively degrades STING, inhibits microglial pyroptosis, and provides robust neuroprotection in SAH. This work establishes a novel biomimetic nanomedicine strategy for SAH therapy and opens new avenues for treating neuroinflammation\u2010related disorders.<\/jats:p>","DOI":"10.1002\/advs.76553","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T18:31:57Z","timestamp":1783794717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeted Degradation of STING by a Neutrophil Membrane\u2010Coated Nanoplatform Suppresses Microglial Pyroptosis After Subarachnoid Hemorrhage"],"prefix":"10.1002","volume":"13","author":[{"given":"Ruotian","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaikun","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital 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