{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:59:53Z","timestamp":1791197993103,"version":"4.1.0"},"reference-count":65,"publisher":"Wiley","issue":"55","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Oral nanomedicines that modulate gut microbiota and gut\u2013brain interactions are crucial for effectively treating inflammatory bowel disease (IBD) and associated psychiatric disorders, such as anxiety and depression. However, the underlying causes of psychiatric disorders in patients with IBD remain unclear, and effective treatment strategies have yet to be established. Herein, we developed oral gastroprotective \u03b2G@Apr\u2010WPG NMs (\u03b2\u2010glucan armored apremilast encapsulating tryptophan\u2010poly(lactic\u2010co\u2010glycolic acid)\u2010glutathione nanomicelles). This system effectively treats IBD and associated anxiety\/depression by modulating the microbiota\u2013gut\u2013brain axis. \u03b2G@Apr\u2010WPG NMs demonstrated gastroprotection enhances retention, and enables sustained release within the inflamed colon, enhances drug solubility, and inflammation\u2010responsive apremilast release significantly improving oral therapeutic efficacy. Oral \u03b2G@Apr\u2010WPG NMs administration outperformed free apremilast by restoring gut barrier integrity, reducing histopathological damage, and modulating microbial dysbiosis. Systemic inflammation and neuroinflammation were markedly suppressed. Notably, the \u03b2G@Apr\u2010WPG NMs ameliorated anxiety\u2010 and depression\u2010like symptoms, as well as cognitive deficits in colitis\u2010induced mice, highlighting its therapeutic impact beyond the gut. Addressing reduced efficacy of conventional therapies, this multifunctional \u03b2G@Apr\u2010WPG NMs platform offers safe, simple, and highly efficient therapeutic strategy integrating targets\u00a0intestinal inflammation, microbiota\u2013gut\u2013brain axis\u00a0modulation, in the pathogenesis of\u00a0IBD with comorbid neuropsychiatric disorders with confirmed safety.<\/jats:p>","DOI":"10.1002\/advs.76566","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:36:45Z","timestamp":1784554605000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Targeted \u03b2\u2010Glucan\u2010Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis\u2010Associated Gut Microbiota and Alleviates Ulcerative Colitis\u2010Associated Anxiety, Depression, and Neuropsychiatric Behaviors"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1881-0915","authenticated-orcid":false,"given":"Chandrashekhar","family":"Jori","sequence":"first","affiliation":[{"name":"Chemical Biology Unit Institute of Nano Science and Technology  Mohali Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Shaney Rehman","sequence":"additional","affiliation":[{"name":"Department of Toxicology School of Chemical and Life Sciences Jamia Hamdard  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taruna","family":"Lamba","sequence":"additional","affiliation":[{"name":"Immunology Laboratory Department of Biomedical Engineering Indian Institute of Technology  Ropar, Rupnagar Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Chemical Biology Unit Institute of Nano Science and Technology  Mohali Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jattin","family":"Kumar","sequence":"additional","affiliation":[{"name":"Chemical Biology Unit Institute of Nano Science and Technology  Mohali Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneesh","family":"Ali","sequence":"additional","affiliation":[{"name":"Chemical Biology Unit Institute of Nano Science and Technology  Mohali Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajesh","family":"Joshi","sequence":"additional","affiliation":[{"name":"Chemical Biology Unit Institute of Nano Science and Technology  Mohali Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf","family":"Ali","sequence":"additional","affiliation":[{"name":"Chemical Biology Unit Institute of Nano Science and Technology  Mohali Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6318-6506","authenticated-orcid":false,"given":"Suhel","family":"Parvez","sequence":"additional","affiliation":[{"name":"Department of Toxicology School of Chemical and Life Sciences Jamia Hamdard  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javed N.","family":"Agrewala","sequence":"additional","affiliation":[{"name":"Immunology Laboratory Department of Biomedical Engineering Indian Institute of Technology  Ropar, Rupnagar Punjab India"},{"name":"Department of Biotechnology Punjab University  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehan","family":"Khan","sequence":"additional","affiliation":[{"name":"Immunology Laboratory Department of Biomedical Engineering Indian Institute of Technology  Ropar, Rupnagar Punjab India"},{"name":"Department of Biotechnology Punjab University  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00018.2018"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010020\u20100090\u20108"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b03569"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3TB00276D"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422\u2010020\u20100332\u20107"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001743\u20101"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(21)00014\u20105"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izaa349"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adf3887"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001481\u2010w"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010022\u201001479\u2010w"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.103908"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2026.103322"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001486\u20105"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2025.101982"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010020\u20100651\u20106"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010019\u20100439\u2010x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.08.041"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad1329"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102016\u2010313099"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564\u2010018\u20100337\u2010x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010020\u20101705\u2010z"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201044742\u2010y"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.05.001"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(19)30414\u20105"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.07.033"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.12.032"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.12.032"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.04.007"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2019.10.006"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002434\u20103"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202304735"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201066634\u20105"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmz127"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010021\u201002175\u20102"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201005470\u20104"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010019\u201003190\u20106"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010022\u201005226\u20105"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201069745\u2010x"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.152849"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2025.123537"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202000116"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00036.2002"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.4.571"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.12.1535"},{"issue":"8","key":"e_1_2_10_47_1","first-page":"4557","article-title":"A Guide to Histomorphological Evaluation of Intestinal Inflammation in Mouse Models","volume":"7","author":"Erben U.","year":"2014","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813485099"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024447"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/73.6.1131S"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9524075"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2014.18.4.279"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.05.004"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1089600"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105296"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00060\u201018"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2024.03.016"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1103836"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41538\u2010024\u201000339\u2010x"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010023\u201001028\u20107"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsle\/fnad116"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20180794"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010021\u201001421\u20106"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12079\u2010022\u201000695\u2010x"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2024.11.028"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201068770\u20100"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.76566","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.76566","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.76566","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:07:11Z","timestamp":1791194831000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.76566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,20]]},"references-count":65,"journal-issue":{"issue":"55","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/advs.76566"],"URL":"https:\/\/doi.org\/10.1002\/advs.76566","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,20]]},"assertion":[{"value":"2026-03-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e76566"}}