{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:42:10Z","timestamp":1792590130984,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92459303"],"award-info":[{"award-number":["92459303"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573347"],"award-info":[{"award-number":["82573347"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20383"],"award-info":[{"award-number":["U21A20383"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82341018"],"award-info":[{"award-number":["82341018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2024ZD0525700"],"award-info":[{"award-number":["2024ZD0525700"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2025ZD0544802"],"award-info":[{"award-number":["2025ZD0544802"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2023B1212060013"],"award-info":[{"award-number":["2023B1212060013"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Accurate prediction of lymph node metastasis (LNM) and survival outcomes is crucial for personalized treatment in bladder cancer, yet remains clinically challenging. This study aimed to develop a Cytology\u2010based multitask predictive Network (CytoNet) to simultaneously predict LNM and disease\u2010free survival (DFS) in bladder cancer, and to evaluate its generalizability in cervical and thyroid cancers. This study included a multicenter cohort of 5273 patients, with bladder cancer (n = 1134), cervical cancer (n = 598), and thyroid cancer (n = 3541). CytoNet was constructed through a three\u2010stage pipeline comprising self\u2010supervised pretraining, supervised fine\u2010tuning, and multitask prediction. In bladder cancer, CytoNet achieved an area under the curve (AUC) of 0.831\u20100.881 for LNM prediction and a C index of 0.680\u20100.710 for DFS prediction across all cohorts, outperforming single\u2010task models and standard radiological assessments. In cervical cancer, CytoNet demonstrated robust performance for both LNM prediction (AUC 0.847\u20100.862) and DFS prediction (C index 0.690\u20100.709), while in thyroid cancer, it achieved an AUC of 0.819\u20100.855 for LNM prediction. In conclusion, CytoNet represents a reliable tool for predicting LNM and prognosis from cytopathology images across multiple cancer types, showing potential as a valuable adjunct to current clinical decision\u2010making. Further prospective validation is warranted to assess its clinical utility.<\/jats:p>","DOI":"10.1002\/advs.76577","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:01:10Z","timestamp":1792587670000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multitask Deep Learning Model for Predicting Lymph Node Metastasis and Disease\u2010Free Survival From Cytology Images in Bladder Cancer: A Multicenter Study With Pan\u2010Cytology Validation"],"prefix":"10.1002","author":[{"given":"Guibin","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Centre for Urological Diseases  Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Centre for Urological Diseases  Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Centre for Urological Diseases  Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Huang","sequence":"additional","affiliation":[{"name":"CellsVision Medical Technology Services Co., Ltd  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runnan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Centre for Urological Diseases  Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Centre for Urological Diseases  Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Centre for Urological Diseases  Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoxuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Centre for Urological Diseases  Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Centre for Urological Diseases  Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxiao","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Centre for Urological Diseases  Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Lin","sequence":"additional","affiliation":[{"name":"CellsVision Medical Technology Services Co., Ltd  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Chen","sequence":"additional","affiliation":[{"name":"CellsVision Medical Technology Services Co., Ltd  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nengtai","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Pathology Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Centre for Urological Diseases  Guangdong China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumour Epigenetics and Gene Regulation Guangdong\u2010Hong Kong Joint Laboratory for RNA Medicine Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoxu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Urology Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Centre for Urological Diseases  Guangdong China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumour Epigenetics and Gene Regulation Guangdong\u2010Hong Kong Joint Laboratory for RNA Medicine Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.70019"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2023.08.016"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.02762"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585\u2010018\u20100066\u20101"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.12.018"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585\u2010023\u201000842\u2010y"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2018.0072"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010023\u201000468\u20109"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(22)01188\u20106"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.11.012"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010023\u201002640\u2010w"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2022.07.004"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010021\u201001614\u20100"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010021\u201000560\u20107"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007894\u2010z"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO\u201024\u201002679"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2025.12.007"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.220329"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201017\u20101510"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.04.003"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15930"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010024\u201002915\u2010w"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.17598"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000118"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102566"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201023\u20100570"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22923"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202508977"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.8731"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2025.102242"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noac166"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2589\u20107500(22)00040\u20101"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201022188\u2010y"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201024\u20104190"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.07.029"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2025.09.001"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2401497"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010024\u201012467\u20104"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2022.08.015"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010022\u201009270\u20109"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2025.03.017"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2021.09.028"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31952"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034442"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(21)00004\u20108"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.76577","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.76577","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.76577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:01:12Z","timestamp":1792587672000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.76577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,21]]},"references-count":46,"alternative-id":["10.1002\/advs.76577"],"URL":"https:\/\/doi.org\/10.1002\/advs.76577","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,21]]},"assertion":[{"value":"2026-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e76577"}}