{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T10:54:46Z","timestamp":1791543286090,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"56","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203379"],"award-info":[{"award-number":["82203379"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cancer stem cells are pivotal in cancer progression, yet the mechanisms underlying the stemness properties of neuroblastoma cells remain largely unclear. By analyzing data from the TARGET\u2010NBL and GEO databases, WDR72 is identified as a cancer stem cell marker that significantly correlates with high\u2010risk of neuroblastoma and poor prognosis in neuroblastoma patients. It is found that knocking down WDR72 in neuroblastoma cells suppresses cell proliferation and migration, while inducing apoptosis. An increased expression of WDR72 is detected in neuroblastoma cells with enhanced stemness properties, while silencing WDR72 reduces the stemness of these cells. Mechanistically, we find that the upregulation of WDR72 is mediated by m6A modifications in its 3\u2019 UTR induced by the METTL14\u2010IGF2BP1 axis. Further investigation into the downstream regulatory mechanisms of WDR72 demonstrates that WDR72 interacts with TRIM31, blocking the ubiquitination and subsequent degradation of the CBX8 protein. This interaction stabilizes CBX8, contributing to the maintenance of neuroblastoma cell stemness. This study reveals that the upregulation of WDR72 via the METTL14\u2010IGF2BP1 axis enhances the stemness properties of neuroblastoma cells by stabilizing CBX8 through interaction with TRIM31. These findings provide new insights into the molecular mechanisms driving neuroblastoma malignancy and offer potential therapeutic targets for patients with neuroblastoma.<\/jats:p>","DOI":"10.1002\/advs.76602","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:38:06Z","timestamp":1785447486000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["WDR72 Promotes Neuroblastoma Stemness and Progression by Sequestering TRIM31\u2010Mediated Degradation of CBX8"],"prefix":"10.1002","volume":"13","author":[{"given":"Huijuan","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center For Child Health Guangzhou Medical University  Guangzhou Guangdong 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Guangdong Provincial Clinical Research Center For Child Health Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianbao","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center For Child Health Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiliang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center For Child Health Guangzhou Medical University  Guangzhou Guangdong 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Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center For Child Health Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center For Child Health Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8677-8475","authenticated-orcid":false,"given":"Gautam","family":"Sethi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"NUS Centre for Cancer Research Yong Loo Lin School of Medicine National University of Singapore  Singapore 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