{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T10:54:45Z","timestamp":1791543285141,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"56","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82221003"],"award-info":[{"award-number":["82221003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22579011"],"award-info":[{"award-number":["22579011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52303363"],"award-info":[{"award-number":["52303363"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hainan Province","doi-asserted-by":"publisher","award":["326YXQN0962"],"award-info":[{"award-number":["326YXQN0962"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The emergence of drug\u2010resistant bacteria has brought a grand challenge to the treatment of oral ulcers (OUs). Peroxidase (POD) enzymes catalyze the conversion of hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) into reactive oxygen species (ROS), offering a promising strategy for treating drug\u2010resistant bacterial infections and oral wound therapy. Among them, two\u2010dimensional conjugated metal\u2010organic frameworks (2D\u2010cMOFs) with high \u03c0\u2010\u03c0 conjugated structure and efficient electron transport capability serve as potent POD mimics, enhancing ROS generation for targeted antimicrobial applications. However, the reported single\u2010metal\u2010center 2D cMOFs possess the intrinsically weak adsorption interaction with H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , usually decreasing the conversion of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    to ROS, exhibiting relatively low enzymatic activity and antibacterial performance. Herein, we reported a new class of Ni doped Cu 2D cMOFs, defined as CuNi\u2010HHTP 2D\u2010cMOFs, for constructing dual activity site to enhance the adsorption and activation of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , which significantly facilitates the treatment of OUs. Mechanism investigation reveals the introduction of Ni atom upshifts the d\u2010band center of CuNi\u2010HHTP 2D\u2010cMOFs from \u20102.563 to \u20102.084 eV, which enhances the adsorption and activation of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , endowing its 5.0\u2010fold enhancement in bactericidal efficiency. Besides, the as\u2010made CuNi\u2010HHTP 2D\u2010cMOFs show improved antibacterial performance in vivo, which significantly promote OU healing, with macroscopic wound closure on the 7\n                    <jats:sup>th<\/jats:sup>\n                    day.\n                  <\/jats:p>","DOI":"10.1002\/advs.76605","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:39:05Z","timestamp":1785937145000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Two\u2010Dimensional Conjugated Metal Organic Frameworks with Dual Metal Catalytic Active Sites Enhance POD Activity for Antibacterial Treatment"],"prefix":"10.1002","volume":"13","author":[{"given":"Yixuan","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Geriatric Dentistry, School and Hospital of Stomatology, School of Materials Science and Engineering Peking University Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinqin","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Electrochemical Process and Technology for Materials Beijing University of Chemical Technology  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Geriatric Dentistry, School and Hospital of Stomatology, School of Materials Science and Engineering Peking University Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Dentistry, School and Hospital of Stomatology, School of Materials Science and Engineering Peking University Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Geriatric Dentistry, School and Hospital of Stomatology, School of Materials Science and Engineering Peking University Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanpei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Dentistry, School and Hospital of Stomatology, School of Materials Science and Engineering Peking University Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4407-8785","authenticated-orcid":false,"given":"Youxing","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Electrochemical Process and Technology for Materials Beijing University of Chemical Technology  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Geriatric Dentistry, School and Hospital of Stomatology, School of Materials Science and Engineering Peking University Beijing P. R. China"},{"name":"Peking University Hospital of Stomatology Sanya Division (Sanya Stomatology Center)  Sanya Hainan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1838-6274","authenticated-orcid":false,"given":"Xuliang","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Geriatric Dentistry, School and Hospital of Stomatology, School of Materials Science and Engineering Peking University Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4427-6837","authenticated-orcid":false,"given":"Shaojun","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Geriatric Dentistry, School and Hospital of Stomatology, School of Materials Science and Engineering Peking University Beijing P. R. 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