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Iron is critical for\n                    <jats:italic>H. pylori<\/jats:italic>\n                    \u2019s survival and pathogenicity, as the bacterium relies on maintaining iron homeostasis for normal proliferation, metabolism, and colonization of the stomach. Inspired by this, we propose a \u201cnutritional trap\u201d strategy, using bismuth as \u201cfake iron\u201d to trick the\n                    <jats:italic>H. pylori<\/jats:italic>\n                    \u2019s iron\u2010uptake system, triggering iron starvation. We then developed a bismuth\u2010based nanodrug (Bi\u2010TP@FU, TBF) modified with tea polyphenols and fucoidan for enhanced\n                    <jats:italic>H. pylori<\/jats:italic>\n                    targeting and gastric mucosal penetration. TBF targets and adheres to the surface of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    by binding to the BabA protein, then induces iron starvation and metabolic disorders through competition between bismuth and iron, ultimately killing multidrug\u2010resistant strains without inducing resistance. Interestingly, TBF selectively eliminated pathogens while preserving probiotics, thus maintaining intestinal flora balance, which is superior to quadruple therapy. This novel oral TBF, which relies on a nutritional trap\u2010based bactericidal strategy, offers a new option for antibiotic alternative therapy of bacterial infections.\n                  <\/jats:p>","DOI":"10.1002\/advs.76621","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:49:19Z","timestamp":1784551759000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Disrupting\n                    <i>Helicobacter pylori<\/i>\n                    Iron Homeostasis With Bismuth Nanodrug\u2010Mediated Nutritional Trap for Targeted Gastric Infection Therapy"],"prefix":"10.1002","volume":"13","author":[{"given":"Tianye","family":"Fang","sequence":"first","affiliation":[{"name":"School of Pharmacy China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhe","family":"Tong","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Pharmacy China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5691-6673","authenticated-orcid":false,"given":"Chang","family":"Shu","sequence":"additional","affiliation":[{"name":"School of Pharmacy China Pharmaceutical University  Nanjing China"},{"name":"Key Laboratory of Drug Quality Control and Pharmacovigilance China Pharmaceutical University  Nanjing 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Nanjing China"},{"name":"MOE Joint International Research Laboratory of Animal Health and Food Safety Key Laboratory of Animal Bacteriology Ministry of Agriculture College of Veterinary Medicine Nanjing Agricultural University  Nanjing 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