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While peptide nanofibrils can function as self\u2010delivery systems to activate antigen\u2010presenting cells (APCs), most existing designs rely on complex covalent conjugation to\u00a0\u03b2\u2010sheet\u2010forming motifs. Moreover, the diverse surface properties of various antigenic peptides complicate the rational selection of appropriate adjuvants. Herein, we develop a nanovaccine platform in which antigenic peptides self\u2010assemble into nanofibrils without the need for exogenous \u03b2\u2010sheet\u2010forming sequences. Silica nanoparticles (SiO\n                    <jats:sub>2<\/jats:sub>\n                    NPs) are nucleated and grown directly along these fibrils, resulting in SiO\n                    <jats:sub>2<\/jats:sub>\n                    @fibril nanovaccines with a unique \u201cbeads\u2010on\u2010a\u2010string\u201d morphology. Using amyloid\u2010\u03b2(1\u201042) (A\u03b242) and human papillomavirus (HPV) type 16 E7 (E7) as model antigens, we demonstrate that these nanovaccines significantly enhance the maturation and activation of bone marrow\u2010derived dendritic cells (BMDCs). In an Alzheimer's disease animal model using APP\/PS1 mice, SiO\n                    <jats:sub>2<\/jats:sub>\n                    @A\u03b242 nanovaccines improve motor and cognitive function. Additionally, in an HPV animal model using TC\u20101 tumor\u2010bearing mice, SiO\n                    <jats:sub>2<\/jats:sub>\n                    @E7 nanovaccines suppress tumor growth and increase survival rate. This strategy provides a universal and modular adjuvant platform for peptide\u2010based nanovaccines.\n                  <\/jats:p>","DOI":"10.1002\/advs.76636","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:55:57Z","timestamp":1784022957000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Self\u2010Assembly of Antigenic Peptide Nanofibrils Templates the Growth of Silica Nanoparticles for Nanovaccines"],"prefix":"10.1002","volume":"13","author":[{"given":"Xuecheng","family":"Yang","sequence":"first","affiliation":[{"name":"School of Chemical Engineering Dalian University of Technology  Dalian China"},{"name":"State Key Laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology  Dalian China"},{"name":"Frontiers Science Center for Smart Materials Oriented Chemical Engineering Dalian University of Technology  Dalian 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