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In this review, we use mechanical intelligence to describe the time\u2010dependent capacity of biomaterials, cells, and therapeutic devices to store, transform, and transmit mechanical history during repair. Two forms of memory are central to this view. Scaffolds and implants can preserve or release previous mechanical states through relaxation, residual stress, shape recovery, evolving stiffness, and architecture, whereas cells can carry earlier stiffness or loading exposure into later mechanotransduction, lineage commitment, and niche remodeling. The key question is when these two forms of memory meet during healing, from cell recruitment and matrix formation to callus maturation, load sharing, and rehabilitation. Coupling material and cellular memory may help match scaffold mechanics to cellular decision windows and tissue competence, support osteogenesis, reduce maladaptive responses such as stress shielding or fibrosis, and guide stage\u2010specific scaffolds, adaptive fixation, sensing\u2010assisted modelling, and mechanically timed rehabilitation for personalized bone repair.<\/jats:p>","DOI":"10.1002\/advs.76638","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:12:11Z","timestamp":1784196731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanical Intelligence in Bone Regeneration: Bridging Material and Cellular Memory for Enhanced Healing"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4072-3086","authenticated-orcid":false,"given":"Jin","family":"Tian","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Xi'an 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