{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:51:04Z","timestamp":1792036264084,"version":"4.4.0"},"reference-count":56,"publisher":"Wiley","issue":"57","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22275037"],"award-info":[{"award-number":["22275037"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The clinical translation of cancer vaccines remains limited by the inability to effectively coordinate innate and adaptive immunity. Leveraging the metabolism pattern of the immune system, herein, we report a glucose metabolism\u2010modulatory nanobiohybrid vaccine with superior antitumor immunity via orchestrating cross\u2010presentation\u2010enhanced adaptive immunity and proinflammatory signaling\u2010mediated innate immunity. This nanobiohybrid vaccine is constructed by a nanoscale hydrogen\u2010bonded organic framework (HOF) co\u2010encapsulating glucose oxidase (GOx), and a model antigen, ovalbumin (OVA) (denoted OVA\/GOx@HOF). OVA\/GOx@HOF enables a GOx\u2010mediated enzyme reaction that consumes glucose and produces H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    within dendritic cells (DCs) in controlled kinetics, which disrupts intracellular glucose metabolism and causes redox imbalance but minimally impacts cell viability. These effects induce autophagic machinery in DCs that promotes antigen cross\u2010presentation, thereby boosting cytotoxic T cell response. Meanwhile, through RNA sequencing, we found that OVA\/GOx@HOF stimulates innate immunity through an NF\u2010\u03baB signaling\u2010mediated and endogenous hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S)\u2010enhanced NLRP3 inflammasome pathway, leading to significant DC maturation. In a melanoma tumor model, this nanobiohybrid vaccine effectively inhibits tumor growth and metastasis, and can be applied to encapsulate neoantigens to generate a potent personalized cancer vaccine. Our findings suggested the remarkable potential of enzyme\u2010driven nanobiohybrid materials as a metabolism\u2010modulatory platform for cancer vaccines.\n                  <\/jats:p>","DOI":"10.1002\/advs.76654","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:06:28Z","timestamp":1784635588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Glucose Metabolism\u2010Modulatory Nanobiohybrid Vaccine Platform Promotes Anti\u2010Tumor Immunity by Orchestrating Autophagy\u2010Dependent Cross\u2010Presentation and H\n                    <sub>2<\/sub>\n                    S\u2010Enhanced NLRP3 Inflammasome Signaling"],"prefix":"10.1002","volume":"13","author":[{"given":"Weidong","family":"Wang","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Department of Chemistry Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Gong","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Department of Chemistry Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Department of Chemistry Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianze","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetics and Development of Complex Phenotypes Obstetrics and Gynecology Hospital Children's Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingli","family":"Deng","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Department of Chemistry Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6696-3879","authenticated-orcid":false,"given":"Yannan","family":"Yang","sequence":"additional","affiliation":[{"name":"South Australian Immunogenomics Cancer Institute The University of Adelaide  Adelaide South Australia 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