{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:51:06Z","timestamp":1792036266851,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"57","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Early events that bias germinal\u2010center B cells toward malignant evolution remain incompletely defined. Here, we uncover Sex\u2010determining Region Y Box 5 (\n                    <jats:italic>SOX5<\/jats:italic>\n                    ) as an early\u2010stage epigenetic modifier in myelocytomatosis oncogene (\n                    <jats:italic>MYC<\/jats:italic>\n                    )\u2010driven B\u2010cell lymphoma. Single\u2010cell transcriptomics of lymph nodes from CRISPR\/Cas9\u2010engineered\n                    <jats:italic>\n                      Myc\n                      <jats:sup>Cd19\u2010Cre<\/jats:sup>\n                    <\/jats:italic>\n                    B\u2010cell lymphoma chimeric mice resolve a Ki67\u2013high proliferative compartment at an early stage with enriched\n                    <jats:italic>SOX5<\/jats:italic>\n                    transcripts. CRISPRa, CRISPR knockout, and multi\u2010omic profiling reveal a\n                    <jats:italic>SOX5<\/jats:italic>\n                    \u2010centered chromatin program defined by de novo promoter\u2010proximal occupancy coupled to contraction of promoter accessibility. Mechanistically,\n                    <jats:italic>SOX5<\/jats:italic>\n                    binding at the Proteolytic Signal\u2010Containing Nuclear Protein (\n                    <jats:italic>PCNP<\/jats:italic>\n                    ) promoter represses its transcription, thereby reducing apoptosis and alleviating G2\/M arrest. Consequently, B\u2010cell\u2013targeted adeno\u2010associated virus 6 (AAV6)\u2010sh\n                    <jats:italic>SOX5<\/jats:italic>\n                    reduces Ki67\u2010positive\n                    <jats:italic>PAX5<\/jats:italic>\n                    \u2010positive malignant B cells and partially restores follicular architecture. Together,\n                    <jats:italic>SOX5<\/jats:italic>\n                    \u2010mediated, promoter\u2010centric repression of\n                    <jats:italic>PCNP<\/jats:italic>\n                    and other effectors installs and maintains an early\u2010stage proliferative state in\n                    <jats:italic>MYC<\/jats:italic>\n                    \u2010driven B\u2010cell lymphoma, which nominates\n                    <jats:italic>SOX5<\/jats:italic>\n                    \u2010directed intervention as a candidate therapeutic strategy for further investigation.\n                  <\/jats:p>","DOI":"10.1002\/advs.76656","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T20:33:31Z","timestamp":1784320411000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SOX5 Orchestrates Malignant Evolution via Promoter\u2010Centric Chromatin Remodeling in MYC\u2010Driven B\u2010Cell Lymphoma"],"prefix":"10.1002","volume":"13","author":[{"given":"Yiyou","family":"Mao","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Harbin Medical University Cancer Hospital  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyuan","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Harbin Medical University Cancer Hospital  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Qin","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Genomics Genomics Research Center (Key Laboratory of Gut Microbiota and Pharmacogenomics of Heilongjiang Province) College of Pharmacy Harbin Medical University  Harbin China"},{"name":"Department of Pharmacy National Key Laboratory of Frigid Zone Cardiovascular Diseases Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruilin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology and Endocrinology 962<sup>ed<\/sup> Hospital of Joint Logistic Support Force of the Chinese People's Liberation Army  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0362-7075","authenticated-orcid":false,"given":"Jianli","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Harbin Medical University Cancer Hospital  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8116-5293","authenticated-orcid":false,"given":"Qingyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Harbin Medical University Cancer Hospital  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1480-6262","authenticated-orcid":false,"given":"Yuwei","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Harbin Medical University Cancer Hospital  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010023\u201001559\u20101"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024024496"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)02705\u20108"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024025454"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024024788"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020911"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI179703"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2024.09.007"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2025017282"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/ITT.S543117"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010026\u201009837\u2010y"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418\u2010026\u201001758\u2010x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007135\u20103"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201054152\u2010x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010025\u201007660\u20107"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3724\/abbs.2022075"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404784"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185\u2010015\u20101823\u2010z"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020780"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201062615\u2010y"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.62347\/JCGQ1004"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0294729"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201008085\u20106"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436\u2010019\u20100657\u20100"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2023.09.007"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022018752"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418\u2010024\u201001322\u20105"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024025500"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010023\u201000897\u20103"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41573\u2010023\u201000128\u20103"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.70394"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010024\u201002986\u20109"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023021243"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(24)00166\u20102"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010022\u201000832\u2010w"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1548886"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.7102"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201024\u20100984"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024026534"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001780\u2010w"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.76656","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.76656","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.76656","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:32:39Z","timestamp":1792035159000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.76656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,17]]},"references-count":40,"journal-issue":{"issue":"57","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/advs.76656"],"URL":"https:\/\/doi.org\/10.1002\/advs.76656","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,17]]},"assertion":[{"value":"2026-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e76656"}}