{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:51:40Z","timestamp":1792036300301,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"57","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["K3010325101"],"award-info":[{"award-number":["K3010325101"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFF1107600"],"award-info":[{"award-number":["2025YFF1107600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Obesity is a major risk factor for cognitive impairment and related neurodegenerative disorders. Whole grains are rich in polyphenols and dietary fiber, with intake associated with improvements in obesity and cognitive deficits. Gut microbial genes encode enzymes that metabolize dietary polyphenols, thereby influencing host metabolic and neurological health; however, the specific functional microbes and enzymes involved remain largely unknown. Here, we demonstrate that germinated quinoa (GQF), a polyphenol\u2010enriched whole\u2010grain intervention, alleviates high\u2010fat diet\u2010induced cognitive impairment and restores gut microbial diversity more effectively than native quinoa (QF). These benefits correlate with enriched\n                    <jats:italic>Roseburia<\/jats:italic>\n                    abundance and enhanced carbohydrate\u2010active enzyme (CAZyme) gene profiles, particularly genes encoding feruloyl esterase (FAE). GQF exerts neuroprotective effects via a microbiota\u2010substrate co\u2010dependent pattern, rather than simply relying on gut microbiota alone. Specifically, GQF selectively promotes FAE\u2010harboring\n                    <jats:italic>Roseburia hominis<\/jats:italic>\n                    and\n                    <jats:italic>R. intestinalis<\/jats:italic>\n                    proliferation, thereby facilitating the release of bound ferulic acid (FA) from GQF. Liberated FA promotes neuronal growth and synaptic plasticity by activating PINK1\/Parkin\u2010dependent hippocampal mitophagy. These results underscore the indispensable role of specific gut microbes in unlocking the nutritional efficacy of GQF. In conclusion, dietary GQF and its microbe\u2010releasable FA represent a natural nutritional strategy, providing a promising preventive and adjuvant approach for metabolic\u2010related cognitive dysfunction.\n                  <\/jats:p>","DOI":"10.1002\/advs.76686","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:06:30Z","timestamp":1784549190000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gut Microbial Release of Ferulic Acid From Germinated Quinoa Alleviates Obesity\u2010Associated Cognitive Impairment by Activating Hippocampal Mitophagy Associated with PINK1\/Parkin Pathway"],"prefix":"10.1002","volume":"13","author":[{"given":"Yongli","family":"Lan","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wengang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Academy of Agriculture and Forestry Sciences Laboratory for Research and Utilization of Qinghai Tibet Plateau Germplasm Resources Qinghai University  Xining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition Xijing Hospital Air Force Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyang","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Song","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Northwest A&amp;F University  Yangling Shaanxi 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