{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:29:32Z","timestamp":1786634972660,"version":"build-2736575974"},"reference-count":1,"publisher":"Wiley","issue":"45","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This Correspondence is a formal response to the Comment by Dr. Machado regarding our publication \u201cCreatine Promotes Endometriosis by Inducing Ferroptosis Resistance via Suppression of PrP.\u201d We address several conceptual concerns raised in the Comment and clarify the physiological relevance of creatine concentrations, the methodological framework for PrP target identification, and the interpretation of human cohort data. We further provide evidence supporting creatine accumulation in endometriotic lesions and peritoneal fluid, and clarify the experimental basis for PrP target identification using integrated biochemical, computational, and functional analyses. Rather than demonstrating a direct molecular interaction, our findings instead provide convergent evidence consistent with PrP acting as a candidate functional target of creatine. We also reinforce the association between creatine exposure, ferroptosis resistance, and lesion progression, while acknowledging that definitive biochemical validation of direct binding remains to be established. Importantly, our study provides translational support for mechanistic investigations in endometriosis, rather than establishing a definitive clinical biomarker. Collectively, we highlight the metabolic significance of creatine\u2013PrP signaling in endometriosis and discuss future directions for mechanistic and clinical validation.<\/jats:p>","DOI":"10.1002\/advs.76708","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:16:42Z","timestamp":1784549802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reply to \u201cReassessing the Proposed Creatine\u2013PrP Axis in Endometriosis: Methodological and Mechanistic Considerations\u201d"],"prefix":"10.1002","volume":"13","author":[{"given":"Siman","family":"Chen","sequence":"first","affiliation":[{"name":"Obstetrics &amp; Gynecology Hospital of Fudan University Shanghai Key Lab of Reproduction and Development Shanghai Key Lab of Female Reproductive Endocrine Related Diseases Fudan University  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Ma","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Reproductive Health Research Department of Obstetrics and Gynecology The First Affiliated Hospital of Xiamen University, School of Medicine Xiamen University  Fujian People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukai","family":"Liu","sequence":"additional","affiliation":[{"name":"Obstetrics &amp; Gynecology Hospital of Fudan University Shanghai Key Lab of Reproduction and Development Shanghai Key Lab of Female Reproductive Endocrine Related Diseases Fudan University  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqi","family":"Zhong","sequence":"additional","affiliation":[{"name":"Xinglin College Nantong University  Nantong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Wei","sequence":"additional","affiliation":[{"name":"Obstetrics &amp; Gynecology Hospital of Fudan University Shanghai Key Lab of Reproduction and Development Shanghai Key Lab of Female Reproductive Endocrine Related Diseases Fudan University  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9276-0722","authenticated-orcid":false,"given":"Mingqing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Reproductive Immunology The International Peace Maternity and Child Health Hospital School of Medicine Shanghai Jiao Tong University Shanghai People's Republic of China"},{"name":"Shanghai Key Laboratory of Embryo Original Diseases  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2512-9703","authenticated-orcid":false,"given":"Xiaoyong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Obstetrics &amp; Gynecology Hospital of Fudan University Shanghai Key Lab of Reproduction and Development Shanghai Key Lab of Female Reproductive Endocrine Related Diseases Fudan University  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202403517"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.76708","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.76708","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.76708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:39:31Z","timestamp":1786631971000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.76708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,20]]},"references-count":1,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/advs.76708"],"URL":"https:\/\/doi.org\/10.1002\/advs.76708","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,20]]},"assertion":[{"value":"2026-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e76708"}}