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Here, we report an injectable, ultrasound (US)\u2010activated piezoelectric hydrogel that programmably couples neurogenesis and macrophage reprogramming to accelerate diabetic wound repair. The hydrogel is constructed from dynamic covalent networks among acyl hydrazide hyaluronic acid, benzene boronic acid modified oxidized sodium alginate, and epigallocatechin 3\u2010gallate, and integrates a neuroactive self\u2010assembling peptide and piezoelectric PLLA nanofibers. This design confers the hydrogel with injectability, self\u2010healing, tissue adhesion, and US\u2010triggered electrical signaling. In vitro, the hydrogel under US promotes M2 macrophage polarization and enhances axonal outgrowth of dorsal root ganglion neurons, establishing bidirectional neurogenesis\u2010macrophage crosstalk. In a type II diabetic mouse model, the hydrogel markedly accelerates wound closure, elevates the M2\/M1 ratio, enhances reinnervation and angiogenesis, and improves collagen remodeling. Transcriptomic analysis of cells and wound tissues identifies coordinated regulation of mitochondrial function and oxidative phosphorylation as a central mechanism. In a diabetic rabbit ear model, the hydrogel with US further attenuates hypertrophic scar formation. This programmable piezoelectric hydrogel converts noninvasive US into spatially confined bioelectrical and biochemical cues, offering a promising strategy to overcome multifactorial barriers in diabetic wound healing.<\/jats:p>","DOI":"10.1002\/advs.76721","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:42:30Z","timestamp":1785242550000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ultrasound\u2010Activated Piezoelectric Neuroimmune Hydrogel Orchestrates Neurogenesis\u2010Macrophage Crosstalk in Diabetic Wound Healing"],"prefix":"10.1002","volume":"13","author":[{"given":"Kai","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Xijing Hospital The Fourth Military Medical University  Xi'an China"},{"name":"Diabetic Foot Center The Air Force Hospital of Eastern Theater of PLA  Nanjing 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