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To achieve this goal, biodegradable molybdenum sulfide nanoparticles (MoS\n                    <jats:sub>X<\/jats:sub>\n                    NPs) were synthesized to increase molybdenum enzyme activity and thus effectively potentiate anti\u2010tumor immunity by integrating molybdenum\u2010based metalloimmunotherapy with hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) gas therapy. This dual\u2010modality approach not only amplified immune activation but also triggered the stimulator of interferon genes (STING) signaling pathway and modulated purine metabolic networks, thereby orchestrating a comprehensive enhancement of anti\u2010tumor immune responses. In detail, the biodegradable MoS\n                    <jats:sub>X<\/jats:sub>\n                    NPs exhibited excellent GSH\u2010responsiveness, triggering the rapid release of H\n                    <jats:sub>2<\/jats:sub>\n                    S and molybdate ions (MoO\n                    <jats:sub>4<\/jats:sub>\n                    <jats:sup>2\u2212<\/jats:sup>\n                    ). H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010mediated mitochondrial damage elicited the release of mitochondrial DNA (mtDNA), which activated the STING pathway, while MoO\n                    <jats:sub>4<\/jats:sub>\n                    <jats:sup>2\u2212<\/jats:sup>\n                    further enhanced the activation of the cGAS\u2010STING signaling pathway. As the catalytic moiety of molybdenum, MoO\n                    <jats:sub>4<\/jats:sub>\n                    <jats:sup>2\u2212<\/jats:sup>\n                    regulated cellular purine metabolic reprogramming and increased UA level with the tumor, thereby achieving synergistic anti\u2010tumor immune responses. This study proposes a molybdenum\u2010based nanocatalytic strategy to improve purine metabolic networks, activate T\u2010cell, and trigger a strong anti\u2010tumor response, thereby achieving precision metabolic\u2010immune therapy for tumors.\n                  <\/jats:p>","DOI":"10.1002\/advs.76726","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:21:31Z","timestamp":1784805691000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Engineering\u2010Modulated Molybdenum Enzymes Strategy for Tumor\u2010Specific Metabolic\u2010Immunotherapy"],"prefix":"10.1002","volume":"13","author":[{"given":"Xiaoxiao","family":"Pan","sequence":"first","affiliation":[{"name":"Institute of Functional Nano &amp; Soft Materials (FUNSOM) Biomedical\u2010BasicResearch\u2010Center (BBRC) of Jiangsu Province Soochow University  Suzhou 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