{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:48:35Z","timestamp":1792417715373,"version":"4.4.0"},"reference-count":60,"publisher":"Wiley","issue":"58","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    CEP55, a centrosomal protein frequently overexpressed in multiple cancers, is implicated in regulation of genomic instability and PI3K\/AKT pathway activation, yet its role in tumor progression and the tumor microenvironment remains incompletely defined. Here, we developed an inducible Cep55 knockout (KO) mouse model and complementary primary, immortalized, and transformed mouse embryonic fibroblast (MEF) systems and employ integrative multi\u2010omics analyses to define CEP55\u2010driven mechanisms and validated findings in human cancer datasets. Cep55 deletion is well tolerated in adult tissues but significantly delays tumor onset and progression in E1A\/Ras\u2010driven models and prolongs survival in PTEN\u2010deficient cancer models. Mechanistically, spatial transcriptomic and proteomic analyses revealed that CEP55 regulates extracellular matrix (ECM) remodeling, integrin signaling, and cell adhesion pathways, AKT\/ERK signaling and cellular stress responses. Importantly, loss of Cep55 also reprograms the tumor immune microenvironment, reducing tumor\u2010supportive macrophage polarization and enhancing antigen\u2010specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell responses in vitro. Collectively, these findings demonstrate that CEP55 is dispensable for adult tissue homeostasis but plays a critical role in tumor progression by coordinating oncogenic signaling, extracellular matrix dynamics, and tumor\u2013immune interactions and highlight it as a potential therapeutic target in aggressive and immune\u2010resistant cancers.\n                  <\/jats:p>","DOI":"10.1002\/advs.76782","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:34:31Z","timestamp":1786372471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic Ablation and Multi\u2010Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9831-0319","authenticated-orcid":false,"given":"Behnam","family":"Rashidieh","sequence":"first","affiliation":[{"name":"Mater Research Institute The University of Queensland Translational Research Institute  Brisbane QLD Australia"},{"name":"Cancer Research Program QIMR Berghofer Medical Research Institute  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5857-0124","authenticated-orcid":false,"given":"Yuanhao","family":"Yang","sequence":"additional","affiliation":[{"name":"Mater Research Institute The University of Queensland Translational Research Institute  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Louise","family":"Bain","sequence":"additional","affiliation":[{"name":"Cancer Research Program QIMR Berghofer Medical Research Institute  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2518-1340","authenticated-orcid":false,"given":"Phillip","family":"Theron","sequence":"additional","affiliation":[{"name":"Mater Research Institute The University of Queensland Translational Research Institute  Brisbane QLD Australia"},{"name":"Cancer Research Program QIMR Berghofer Medical Research Institute  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina","family":"Vosloo","sequence":"additional","affiliation":[{"name":"Mater Research Institute The University of Queensland Translational Research Institute  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Keshvari","sequence":"additional","affiliation":[{"name":"Mater Research Institute The University of Queensland Translational Research Institute  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0060-3501","authenticated-orcid":false,"given":"Parinaz","family":"Ahangar","sequence":"additional","affiliation":[{"name":"Australian Institute for Bioengineering and Nanotechnology The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brydie","family":"Bowden","sequence":"additional","affiliation":[{"name":"School of Environment and Science Griffith University  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon M.","family":"Tria","sequence":"additional","affiliation":[{"name":"Cancer Research Program QIMR Berghofer Medical Research Institute  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben B.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Molecular &amp; Cellular Biology University of Adelaide School of Biological Sciences  Adelaide SA Australia"},{"name":"South Australian Health and Medical Research Institute  Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Isenmann","sequence":"additional","affiliation":[{"name":"South Australian Health and Medical Research Institute  Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0076-2967","authenticated-orcid":false,"given":"Nicholas J. Westra","family":"van Holthe","sequence":"additional","affiliation":[{"name":"Australian Institute for Bioengineering and Nanotechnology The University of Queensland  Brisbane Queensland Australia"},{"name":"ARC Centre of Excellence in Quantum Biotechnology  St Lucia Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zherui","family":"Xiong","sequence":"additional","affiliation":[{"name":"Cancer Research Program QIMR Berghofer Medical Research Institute  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani","family":"Vu","sequence":"additional","affiliation":[{"name":"Cancer Research Program QIMR Berghofer Medical Research Institute  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sowmya","family":"Sharma","sequence":"additional","affiliation":[{"name":"Cancer Research Program QIMR Berghofer Medical Research Institute  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmerom","family":"Sengal","sequence":"additional","affiliation":[{"name":"Mater Research Institute The University of Queensland Translational Research Institute  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9370-1516","authenticated-orcid":false,"given":"J. 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