{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T13:06:20Z","timestamp":1785157580201,"version":"3.55.0"},"reference-count":85,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32192454"],"award-info":[{"award-number":["32192454"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32272971"],"award-info":[{"award-number":["32272971"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Circular RNAs (circRNAs) are dynamically remodeled during infection, yet how viruses exploit circRNA\u2010RNA binding protein (RBP) circuits remains poorly understood. Here, we report a\n                    <jats:italic>cGLIS3<\/jats:italic>\n                    \u2010IGF2BP2\u2010linked TNF\u2010\u03b1 regulatory axis triggered by deltacoronavirus infection to inhibit antiviral innate immunity. The host m\n                    <jats:sup>6<\/jats:sup>\n                    A reader insulin\u2010like growth factor 2 mRNA\u2010binding protein 2 (IGF2BP2) and viral nucleocapsid (N) protein promote biogenesis of the m\n                    <jats:sup>6<\/jats:sup>\n                    A\u2010modified\n                    <jats:italic>cGLIS3<\/jats:italic>\n                    by strengthening the\n                    <jats:italic>GLIS3 exon 3<\/jats:italic>\n                    circulation. Interaction assay reveals that K\u2010Homology domain of IGF2BP2 or the linker region of viral protein N binds to\n                    <jats:italic>GLIS3<\/jats:italic>\n                    pre\u2010mRNA to achieve\n                    <jats:italic>cGLIS3<\/jats:italic>\n                    biogenesis, respectively. IGF2BP2 stabilizes the m\n                    <jats:sup>6<\/jats:sup>\n                    A\u2010modified\n                    <jats:italic>cGLIS3<\/jats:italic>\n                    against RNase L\u2010mediated degradation.\n                    <jats:italic>cGLIS3<\/jats:italic>\n                    attenuates IGF2BP2\u2010driven TNF\u2010\u03b1 induction to facilitate deltacoronavirus replication by accelerating K48\u2010linked ubiquitin degradation of IGF2BP2. Together, our findings uncover a coronavirus\u2010elicited circRNA\u2010RBP crosstalk circuit to suppress innate immunity, establishing\n                    <jats:italic>cGLIS3<\/jats:italic>\n                    as a mechanistically defined regulator of virus\u2010host interactions.\n                  <\/jats:p>","DOI":"10.1002\/advs.76822","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T12:43:58Z","timestamp":1785156238000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deltacoronavirus Modulates circRNA\n                    <i>cGLIS3<\/i>\n                    Metabolism to Evade Host Antiviral Response"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6571-8213","authenticated-orcid":false,"given":"Liuyang","family":"Du","sequence":"first","affiliation":[{"name":"MOA Key Laboratory of Animal Virology, Zhejiang Provincial Engineering Research Center of Animal Biological Products Zhejiang University Center For Veterinary Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Wang","sequence":"additional","affiliation":[{"name":"MOA Key Laboratory of Animal Virology, Zhejiang Provincial Engineering Research Center of Animal Biological Products Zhejiang University Center For Veterinary Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujing","family":"Diao","sequence":"additional","affiliation":[{"name":"MOA Key Laboratory of Animal Virology, Zhejiang Provincial Engineering Research Center of Animal Biological Products Zhejiang University Center For Veterinary Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[{"name":"MOA Key Laboratory of Animal Virology, Zhejiang Provincial Engineering Research Center of Animal Biological Products Zhejiang University Center For Veterinary Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[{"name":"MOA Key Laboratory of Animal Virology, Zhejiang Provincial Engineering Research Center of Animal Biological Products Zhejiang University Center For Veterinary Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yan","sequence":"additional","affiliation":[{"name":"MOA Key Laboratory of Animal Virology, Zhejiang Provincial Engineering Research Center of Animal Biological Products Zhejiang University Center For Veterinary Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haimin","family":"Li","sequence":"additional","affiliation":[{"name":"MOA Key Laboratory of Animal Virology, Zhejiang Provincial Engineering Research Center of Animal Biological Products Zhejiang University Center For Veterinary Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiren","family":"Dong","sequence":"additional","affiliation":[{"name":"MOA Key Laboratory of Animal Virology, Zhejiang Provincial Engineering Research Center of Animal Biological Products Zhejiang University Center For Veterinary Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3929-2090","authenticated-orcid":false,"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"MOA Key Laboratory of Animal Virology, Zhejiang Provincial Engineering Research Center of Animal Biological Products Zhejiang University Center For Veterinary Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9763-9569","authenticated-orcid":false,"given":"Jinyan","family":"Gu","sequence":"additional","affiliation":[{"name":"MOA Key Laboratory of Animal Virology, Zhejiang Provincial Engineering Research Center of Animal Biological Products Zhejiang University Center For Veterinary Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8852-1227","authenticated-orcid":false,"given":"Jiyong","family":"Zhou","sequence":"additional","affiliation":[{"name":"MOA Key Laboratory of Animal Virology, Zhejiang Provincial Engineering Research Center of Animal Biological Products Zhejiang University Center For Veterinary Sciences  Hangzhou China"},{"name":"State Key Laboratory For Diagnosis and Treatment of Infectious Diseases First Affiliated Hospital, Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41579-018-0118-9","article-title":"Origin and Evolution of Pathogenic 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