{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:55:51Z","timestamp":1791204951584,"version":"4.1.0"},"reference-count":79,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009139","name":"Deutsches Zentrum f\u00fcr Infektionsforschung","doi-asserted-by":"publisher","award":["TTU02.810"],"award-info":[{"award-number":["TTU02.810"]}],"id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009139","name":"Deutsches Zentrum f\u00fcr Infektionsforschung","doi-asserted-by":"publisher","award":["TTU02.814"],"award-info":[{"award-number":["TTU02.814"]}],"id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009139","name":"Deutsches Zentrum f\u00fcr Infektionsforschung","doi-asserted-by":"publisher","award":["TTU 09.827"],"award-info":[{"award-number":["TTU 09.827"]}],"id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["545546569"],"award-info":[{"award-number":["545546569"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201024\u2010CE92\u20100080"],"award-info":[{"award-number":["ANR\u201024\u2010CE92\u20100080"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Despite significant advancements in drug development and discovery, tuberculosis remains one of the world's deadliest infectious diseases. The rise and global spread of multidrug\u2010resistant strains underscore a critical need for new antibiotics with distinct mechanisms of action. Screening of a myxobacterial extract library uncovered the previously unrecognized antitubercular activity of corramycin, a natural product with potent bactericidal activity against both drug\u2010sensitive and \u2010resistant\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    . Corramycin enters the bacterial cell by exploiting multiple transport systems, and induces DNA double\u2010strand breaks through a novel form of DNA gyrase poisoning. The cryo\u2010electron microscopy structure of\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    gyrase in complex with corramycin reveals that the natural product targets a site overlapping with the binding site of synthetic fluoroquinolones, thereby locking the gyrase in an inactive conformation and preventing re\u2010ligation of DNA. Importantly, its unique mode of binding allows corramycin to overcome fluoroquinolone resistance, highlighting its promise as a novel antibiotic scaffold to address the antimicrobial resistance crisis.\n                  <\/jats:p>","DOI":"10.1002\/advs.76832","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:23:33Z","timestamp":1786371813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in\n                    <i>Mycobacterium tuberculosis<\/i>"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6485-8317","authenticated-orcid":false,"given":"Franziska","family":"Fries","sequence":"first","affiliation":[{"name":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy Saarland University  Saarbr\u00fccken Germany"},{"name":"German Center for Infection Research (DZIF) Partner Site Hannover\u2010Braunschweig  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy Saarland University  Saarbr\u00fccken Germany"},{"name":"German Center for Infection Research (DZIF) Partner Site Hannover\u2010Braunschweig  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Dal Molin","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"},{"name":"Center for Molecular Medicine Cologne (CMMC) University of Cologne  Cologne Germany"},{"name":"German Center for Infection Research (DZIF) Partner Site Bonn\u2010Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u00eblle","family":"Wormser","sequence":"additional","affiliation":[{"name":"Institut Pasteur Universit\u00e9 Paris Cit\u00e9 CNRS UMR 3528 Bacterial Cell Cycle Mechanisms Unit  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Risch","sequence":"additional","affiliation":[{"name":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy Saarland University  Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunsheng","family":"Gao","sequence":"additional","affiliation":[{"name":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy Saarland University  Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth","family":"Prosser","sequence":"additional","affiliation":[{"name":"Microbial Interface Biology Research Center Borstel Leibniz Lung Center  Borstel Germany"},{"name":"German Center for Infection Research (DZIF) Partner Site Hamburg\u2010L\u00fcbeck\u2010Borstel\u2010Riems  Borstel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Gubellini","sequence":"additional","affiliation":[{"name":"Institut Pasteur Universit\u00e9 Paris Cit\u00e9 CNRS UMR 3528 Structural Microbiology Unit  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Mechaly","sequence":"additional","affiliation":[{"name":"Institut Pasteur Plate\u2010Forme de Cristallographie \u2013 C2RT CNRS UMR 3528 Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua B.","family":"Wallach","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8387-1271","authenticated-orcid":false,"given":"Arka","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sari","family":"Rasheed","sequence":"additional","affiliation":[{"name":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy Saarland University  Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Horn","sequence":"additional","affiliation":[{"name":"Organic Chemistry I Saarland University  Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"M\u00fcsken","sequence":"additional","affiliation":[{"name":"Helmholtz Centre for Infection Research (HZI) Central Facility for Microscopy  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kurz","sequence":"additional","affiliation":[{"name":"Sanofi\u2010Aventis Deutschland R&amp;D LGCR\/Chemistry Industriepark Hoechst  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Sonnenkalb","sequence":"additional","affiliation":[{"name":"German Center for Infection Research (DZIF) Partner Site Hamburg\u2010L\u00fcbeck\u2010Borstel\u2010Riems  Borstel Germany"},{"name":"Molecular and Experimental Mycobacteriology Research Center Borstel, Leibniz Lung Center  Borstel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viola","family":"Dreyer","sequence":"additional","affiliation":[{"name":"German Center for Infection Research (DZIF) Partner Site Hamburg\u2010L\u00fcbeck\u2010Borstel\u2010Riems  Borstel Germany"},{"name":"Molecular and Experimental Mycobacteriology Research Center Borstel, Leibniz Lung Center  Borstel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Niemann","sequence":"additional","affiliation":[{"name":"German Center for Infection Research (DZIF) Partner Site Hamburg\u2010L\u00fcbeck\u2010Borstel\u2010Riems  Borstel Germany"},{"name":"Molecular and Experimental Mycobacteriology Research Center Borstel, Leibniz Lung Center  Borstel Germany"},{"name":"National and WHO Supranational Reference Laboratory for Mycobacteria Research Center Borstel Leibniz Lung Center  Borstel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f6nke","family":"Andres","sequence":"additional","affiliation":[{"name":"National and WHO Supranational Reference Laboratory for Mycobacteria Research Center Borstel Leibniz Lung Center  Borstel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Schnappinger","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uli","family":"Kazmaier","sequence":"additional","affiliation":[{"name":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy Saarland University  Saarbr\u00fccken Germany"},{"name":"Organic Chemistry I Saarland University  Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Reiling","sequence":"additional","affiliation":[{"name":"Microbial Interface Biology Research Center Borstel Leibniz Lung Center  Borstel Germany"},{"name":"German Center for Infection Research (DZIF) Partner Site Hamburg\u2010L\u00fcbeck\u2010Borstel\u2010Riems  Borstel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy Saarland University  Saarbr\u00fccken Germany"},{"name":"German Center for Infection Research (DZIF) Partner Site Hannover\u2010Braunschweig  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Rybniker","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"},{"name":"Center for Molecular Medicine Cologne (CMMC) University of Cologne  Cologne Germany"},{"name":"German Center for Infection Research (DZIF) Partner Site Bonn\u2010Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Petrella","sequence":"additional","affiliation":[{"name":"Institut Pasteur Universit\u00e9 Paris Cit\u00e9 CNRS UMR 3528 Bacterial Cell Cycle Mechanisms Unit  Paris France"},{"name":"Institut Pasteur Universit\u00e9 Paris Cit\u00e9 CNRS UMR 3528 Structural Microbiology Unit  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Global Tuberculosis Report 2025(World Health Organization 2025)."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065202"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.ES.2024.29.28.2400420"},{"key":"e_1_2_10_5_1","unstructured":"W.HO Bacterial Priority Pathogens List 2024: bacterial pathogens of public health importance to guide research development and strategies to prevent and control antimicrobial resistance(World Health Organization 2024)."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010020\u201000114\u2010z"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4510"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa4690"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01516\u201020"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202210747"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c13208"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c01564"},{"key":"e_1_2_10_13_1","unstructured":"R.M\u00fcller Compound Resources and Medicinal Chemistry German Center for Infection Research \u00a0https:\/\/www.dzif.de\/en\/compound\u2010resources\u2010and\u2010medicinal\u2010chemistry."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.41.993"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2013706117"},{"key":"e_1_2_10_16_1","volume-title":"Methods for determining bactericidal activity of antimicrobial agents: Approved guideline","author":"Barry A. L.","year":"1999"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0085\u20102015"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009823"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01178\u201016"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201010944\u20104"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.05.073"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1169"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn387"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.TBTB2\u20100027\u20102016"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.1c00643"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1311066110"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2419813122"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth996"},{"key":"e_1_2_10_29_1","volume-title":"Catalogue of Mutations in Mycobacterium Tuberculosis Complex and Their Association with Drug Resistance","year":"2023"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.4c00128"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adl5899"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/24206"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.07.017"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/379225a0"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20130430"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2019.01.004"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20130538"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.120175"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102072\u20108"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01132\u201008"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj5363"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1099\/00221287\u2010132\u20106\u20101685"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102958.2007.05903.x"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3439"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589\u2010022\u201001102\u20107"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594\u2010024\u201001256\u2010z"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012225"},{"key":"e_1_2_10_48_1","unstructured":"A.Von Tesmar \u201cInvestigation of Bacterial Secondary Metabolite Pathways \u201d (PhD diss. Universit\u00e4t des Saarlandes 2017) https:\/\/doi.org\/10.22028\/D291\u201026823."},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5296"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110967"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1525047113"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1604"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201064792\u2010w"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl695"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.25.14416"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab270"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.4c00499"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.4c00774"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2023.12.007"},{"key":"e_1_2_10_60_1","unstructured":"R: A Language and Environment for Statistical Computing. (2023)."},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v012.i05"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20100716\u20101460\u20100_26"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00250\u201013"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469\u20100691.2000.00149.x"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.591866"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1315860110"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.10.124"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201015687\u2010x"},{"key":"e_1_2_10_69_1","volume-title":"Mycobacteria Protocols","author":"Parish M.","year":"2008"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2025.03.005"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666\u20105247(23)00002\u20102"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.5895"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564\u2010022\u201001130\u2010y"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.64898\/2025.12.09.693342"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475\u20102859\u20104\u201018"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-890-0:571"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4169"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444904019158"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2059798319011471"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444912001308"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.76832","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.76832","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.76832","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:41:08Z","timestamp":1791204068000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.76832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,10]]},"references-count":79,"alternative-id":["10.1002\/advs.76832"],"URL":"https:\/\/doi.org\/10.1002\/advs.76832","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,10]]},"assertion":[{"value":"2026-02-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e76832"}}