{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:29:30Z","timestamp":1789694970953,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000485"],"award-info":[{"award-number":["82000485"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Interactions between hepatic metabolism and the gut microbiota play a crucial role in the pathogenesis of metabolic dysfunction\u2010associated steatotic liver disease (MASLD), highlighting the gut\u2010liver axis as a promising therapeutic target. However, little is known about how gut dysbiosis influences the composition of liver\u2010resident microbiota, and how this alteration contributes to disease progression. In this study, 16S rRNA sequencing of liver samples from patients with advanced MASLD reveals a marked reduction in the abundance of\n                    <jats:italic>Bacteroides uniformis<\/jats:italic>\n                    (\n                    <jats:italic>B. uniformis<\/jats:italic>\n                    ), a trend also observed in fecal samples. These findings are replicated in a mouse model, where\n                    <jats:italic>B. uniformis<\/jats:italic>\n                    levels are decreased in both hepatic and gut microbial communities. Notably, gavage of\n                    <jats:italic>B. uniformis<\/jats:italic>\n                    increases its abundance in the liver and attenuates multiple features of advanced MASLD. Further investigation identifies propionic acid (PA) as a key mediator responsible for the protective effects of\n                    <jats:italic>B. uniformis<\/jats:italic>\n                    . Mechanistically, both\n                    <jats:italic>B. uniformis<\/jats:italic>\n                    and PA administration suppress lipid peroxidation and ferroptotic stress in hepatocytes through activating mammalian target of rapamycin phosphorylation and upregulating glutathione peroxidase 4 expression. Taken together, our results uncover a distinctive liver\u2010resident microbiota in advanced MASLD and underscore the therapeutic potential of promoting gut\u2010liver translocation of\n                    <jats:italic>B. uniformis<\/jats:italic>\n                    to curb disease progression.\n                  <\/jats:p>","DOI":"10.1002\/advs.76865","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T12:40:45Z","timestamp":1785156045000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Gut\u2010Liver Translocation of\n                    <i>Bacteroides Uniformis<\/i>\n                    Alleviates Advanced Metabolic Dysfunction\u2010Associated Steatotic Liver Disease by Suppressing Hepatocyte Ferroptosis via Propionic Acid Secretion"],"prefix":"10.1002","author":[{"given":"Haiyang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of General Surgery the First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zun","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of General Surgery the First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery the First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of General Surgery the First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of General Surgery the First Affiliated Hospital of Soochow University  Suzhou 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