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Here, we report that zeolitic imidazole framework\u201090 (ZIF\u201090) can serve as a functional insecticide carrier to overcome resistance by interfering with ABC transporters. Dinotefuran\u2010loaded ZIF\u201090 (Din@ZIF\u201090) was synthesized via a simple and rapid one\u2010pot method and exhibited significantly enhanced toxicity against Din\u2010resistant\n                    <jats:italic>Nilaparvata lugens<\/jats:italic>\n                    . Mechanistically, the nanoformulation selectively inhibited the expression of\n                    <jats:italic>NlABCG3<\/jats:italic>\n                    and\n                    <jats:italic>NlABCH1<\/jats:italic>\n                    , two ABC transporter genes involved in Din resistance, as validated by RNAi. Molecular docking further confirmed the binding potential of Din with the NlABCG3 and NlABCH1 proteins, establishing their functional roles in efflux\u2010based resistance. In addition, Din@ZIF\u201090 afforded enhanced photostability, pH\/ATP\u2010responsive release, superior leaf adhesion, and preserved systemic movement in rice. The nanoformulation also exhibited markedly lower acute contact toxicity to honeybees and was biocompatible with rice, promoting seedling growth. This work presents a novel nanotechnology\u2010based strategy to combat insecticide resistance through targeted modulation of ABC transporters.\n                  <\/jats:p>","DOI":"10.1002\/advs.76866","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:37:11Z","timestamp":1785242231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Interference of ATP\u2010Binding Cassette Transporter by Functional Nano\u2010Delivery System for High Efficiency Management of Insecticide\u2010Resistant\n                    <i>Nilaparvata lugens<\/i>"],"prefix":"10.1002","volume":"13","author":[{"given":"Chengshuai","family":"He","sequence":"first","affiliation":[{"name":"State Key Laboratory of Agricultural and Forestry Biosecurity College of Plant Protection Nanjing Agricultural University  Nanjing 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