{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:58:35Z","timestamp":1785531515467,"version":"3.56.0"},"reference-count":73,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    After spinal cord injury (SCI), the blood\u2010spinal cord barrier (BSCB) is disrupted, and endothelial cells, a critical component of BSCB, undergo proliferation and remodeling to maintain barrier integrity. However, the molecular mechanisms underlying BSCB remodeling remain unclear after SCI. Here, we reveal that Yes\u2010associated protein (YAP), a principal downstream effector of the Hippo signaling pathway, promotes endothelial proliferation and BSCB repair in mice after SCI. First, we found that YAP expression was significantly upregulated and activated in endothelial cells after SCI. Endothelial YAP knockout (YAP\n                    <jats:sup>TEK\u2010cre\/ERT2<\/jats:sup>\n                    \u2010CKO mice) impaired endothelial proliferation, endothelial\u2010astrocyte end\u2010feet reorganization, and tight junction (TJ) integrity, thereby aggravating BSCB disruption and impairing BSCB remodeling and motor functional recovery after SCI. Mechanistically, endothelial YAP\u2010dependent BSCB repair was associated with angiopoietin\u20101 (ANGPT1) expression and PI3K\/AKT pathway activation after SCI. Exogenous ANGPT1 treatment mitigated YAP deficiency\u2010induced inhibition of endothelial proliferation and endothelial barrier disruption via PI3K\/AKT signaling in vitro. Finally, activation of YAP signaling partially mitigated SCI\u2010induced BSCB disruption, ultimately improving motor function recovery. Together, these results identify endothelial YAP signaling as a critical regulator of BSCB remodeling associated with ANGPT1\/PI3K\/AKT pathway and provide a potential therapeutic target for SCI.\n                  <\/jats:p>","DOI":"10.1002\/advs.76891","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:59:11Z","timestamp":1785524351000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endothelial YAP Signaling Promotes Blood\u2010Spinal Cord Barrier Repair in Mice After Spinal Cord Injury"],"prefix":"10.1002","author":[{"given":"Jiawei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopedics (Spine Surgery) The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"},{"name":"School of Pharmacy Hangzhou Normal University  Hangzhou Zhejiang China"},{"name":"Cixi Biomedical Research Institute Wenzhou Medical University  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