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Traditional treatment strategies are unable to achieve the dual goals of virus clearance and tissue repair simultaneously. This study innovatively adopts a hierarchical assembly strategy of \u201cmesoporous carrier anchoring\u2010gel matrix embedding\u201d to construct a functionalized hydrogel (Polymer@mPDA@Gel). Using mesoporous polydopamine (mPDA) as the exclusive anchoring site to load the polymer, forming an efficient photothermal component, and then embedding this component in a gel matrix with strong adhesion and good biocompatibility. Through hierarchical assembly, the photothermal performance, anti\u2010inflammatory performance, and biointerfacial properties are precisely integrated to lay the core foundation for its anti\u2010viral and anti\u2010inflammatory functions. The functionalized hydrogel constructed realizes targeted clearance of MPXV, regulation of inflammation, and integration of tissue repair, providing a new material technology path and theoretical support for the clinical treatment of MPXV infection.<\/jats:p>","DOI":"10.1002\/advs.76926","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:29:57Z","timestamp":1785936597000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Overcoming Transmission Barriers: A Dual\u2010Functional Adhesive Hydrogel for Direct Monkeypox Virus Neutralization and Wound Healing"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7191-4198","authenticated-orcid":false,"given":"Ming","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory Cultivation Base of Research The Affiliated Stomatological Hospital of Nanjing Medical University Prevention 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