{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:47:58Z","timestamp":1785937678701,"version":"3.56.0"},"reference-count":64,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20684"],"award-info":[{"award-number":["U24A20684"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371292"],"award-info":[{"award-number":["82371292"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271430"],"award-info":[{"award-number":["82271430"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M781963"],"award-info":[{"award-number":["2025M781963"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Perioperative stress hyperglycemia is a transient but frequent metabolic disturbance strongly linked to postoperative organ injury and mortality; however, the immunometabolic mechanisms driving this association remain largely undefined. In a two\u2010center cohort of patients undergoing total aortic arch replacement, we identify stress hyperglycemia as an independent determinant of poor postoperative outcomes that associates strongly with CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell loss. Hyperglycemia induces inflammatory PANoptosis in CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells from patients in response to surgical trauma. This results from elevated glucose driving the accumulation and release of succinate from monocytes, which subsequently acts on CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells to compromise mitochondrial integrity and activate ZBP1\u2010mediated PANoptosis. Our findings define a monocyte\u2013T cell metabolic signaling axis that transduces hyperglycemic stress via elevated succinate to adaptive immune cell death and reveal potential therapeutic targets to prevent postoperative immune dysfunction and organ injury, especially for patients with hyperglycemic comorbidities.\n                  <\/jats:p>","DOI":"10.1002\/advs.76968","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:16:57Z","timestamp":1785935817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stress Hyperglycemia Drives CD4\n                    <sup>+<\/sup>\n                    T Cell PANoptosis and Postoperative Organ Injury via Monocyte\u2010Derived Succinate"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7828-2915","authenticated-orcid":false,"given":"Shuai","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Anesthesiology the Second Xiangya Hospital Central South University  Changsha China"},{"name":"Anesthesiology Research Institute of Central South University Changsha  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7736-7607","authenticated-orcid":false,"given":"Xuemei","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology the Second Xiangya Hospital Central South University  Changsha China"},{"name":"Anesthesiology Research Institute of Central South University Changsha  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology the Second Xiangya Hospital Central South University  Changsha China"},{"name":"Anesthesiology Research Institute of Central South University Changsha  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology the Second Xiangya Hospital Central South University  Changsha China"},{"name":"Anesthesiology Research Institute of Central South University Changsha  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology the Second Xiangya Hospital Central South University  Changsha China"},{"name":"Anesthesiology Research Institute of Central South University Changsha  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology the Second Xiangya Hospital Central South University  Changsha China"},{"name":"Anesthesiology Research Institute of Central South University Changsha  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Fu","sequence":"additional","affiliation":[{"name":"Anesthesiology Research Institute of Central South University Changsha  Changsha China"},{"name":"Department of Anesthesiology XiangYa Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyun","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology the Second Xiangya Hospital Central South University  Changsha China"},{"name":"Anesthesiology Research Institute of Central South University Changsha  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3812-8814","authenticated-orcid":false,"given":"Yan","family":"Luo","sequence":"additional","affiliation":[{"name":"Anesthesiology Research Institute of Central South University Changsha  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9892-3118","authenticated-orcid":false,"given":"Kang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Wayne State University  Detroit USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1027-6698","authenticated-orcid":false,"given":"Ruping","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology the Second Xiangya Hospital Central South University  Changsha China"},{"name":"Anesthesiology Research Institute of Central South University Changsha  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0959-455X","authenticated-orcid":false,"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology the Second Xiangya Hospital Central South University  Changsha China"},{"name":"Anesthesiology Research Institute of Central South University Changsha  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.2337\/dc10-0304","article-title":"Prevalence and Clinical Outcome of Hyperglycemia in the Perioperative Period in Noncardiac Surgery","volume":"33","author":"Frisch A.","year":"2010","journal-title":"Diabetes Care"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/SLA.0b013e31827b6bbc","article-title":"Importance of Perioperative Glycemic Control in General Surgery","volume":"257","author":"Kwon S.","year":"2013","journal-title":"Annals of Surgery"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jdiacomp.2018.12.015","article-title":"Stress Hyperglycemia: a Prospective Study Examining the Relationship between Glucose, Cortisol and Diabetes in Myocardial Infarction","volume":"33","author":"Cheung N. W.","year":"2019","journal-title":"Journal of Diabetes and its Complications"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11892-016-0721-y","article-title":"Stress Hyperglycemia during Surgery and Anesthesia: Pathogenesis and Clinical Implications","volume":"16","author":"Palermo N. E.","year":"2016","journal-title":"Current Diabetes Reports"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1161\/hs1001.096194","article-title":"Stress Hyperglycemia and Prognosis of Stroke in Nondiabetic and Diabetic Patients: A Systematic Overview","volume":"32","author":"Capes S. E.","year":"2001","journal-title":"Stroke"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1001\/jamasurg.2021.5561","article-title":"Paradoxical Association of Hyperglycemia and Surgical Complications Among Patients With and Without Diabetes","volume":"157","author":"Chen J. Y.","year":"2022","journal-title":"JAMA Surgery"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1001\/archsurg.141.11.1132","article-title":"Cell Response to Surgery","volume":"141","author":"Ni Choileain N.","year":"2006","journal-title":"Archives of Surgery"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1097\/01.CCM.0000170106.61978.D8","article-title":"Acute Hyperglycemia and the Innate Immune System: Clinical, Cellular, and Molecular Aspects","volume":"33","author":"Turina M.","year":"2005","journal-title":"Critical Care Medicine"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1001\/archsurg.2010.179","article-title":"Postoperative Hyperglycemia and Surgical Site Infection in General Surgery Patients","volume":"145","author":"Ata A.","year":"2010","journal-title":"Archives of Surgery"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jtcvs.2004.09.005","article-title":"Contemporary Results of Surgery in Acute Type A Aortic Dissection: the International Registry of Acute Aortic Dissection Experience","volume":"129","author":"Trimarchi S.","year":"2005","journal-title":"The Journal of Thoracic and Cardiovascular Surgery"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.surg.2007.07.012","article-title":"A Contemporary Analysis of Outcomes for Operative Repair of Type A Aortic Dissection in the United States","volume":"142","author":"Knipp B. S.","year":"2007","journal-title":"Surgery"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1186\/s12933-024-02468-9","article-title":"Monocytes Perturbation Implicated in the Association of Stress Hyperglycemia with Postoperative Poor Prognosis in Non\u2010Diabetic Patients with Stanford Type\u2010A Acute Aortic Dissection","volume":"23","author":"Zhao S.","year":"2024","journal-title":"Cardiovascular Diabetology"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41419-024-07022-9","article-title":"CD36\u2010Mediated Ferroptosis Destabilizes CD4+ T Cell Homeostasis in Acute Stanford Type\u2010A Aortic Dissection","volume":"15","author":"Li H.","year":"2024","journal-title":"Cell Death & Disease"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1186\/s13054-024-05099-4","article-title":"Lymphopenia in Sepsis: a Narrative Review","volume":"28","author":"Wang Z.","year":"2024","journal-title":"Critical Care"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.747467","article-title":"Association of Apoptosis\u2010Mediated CD4+ T Lymphopenia with Poor Outcome after Type A Aortic Dissection Surgery","volume":"8","author":"Luo W.","year":"2021","journal-title":"Frontiers in Cardiovascular Medicine"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/01.ASN.0000048718.43419.44","article-title":"CD4 Cell Lymphopenia and Atherosclerosis in Renal Transplant Recipients","volume":"14","author":"Ducloux D.","year":"2003","journal-title":"Journal of the American Society of Nephrology"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.1016\/j.cell.2024.05.034","article-title":"NLRC5 senses NAD+ Depletion, Forming a PANoptosome and Driving PANoptosis and Inflammation","volume":"187","author":"Sundaram B.","year":"2024","journal-title":"Cell"},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/imr.12909","article-title":"The Regulation of the ZBP1\u2010NLRP3 Inflammasome and Its Implications in Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)","volume":"297","author":"Zheng M.","year":"2020","journal-title":"Immunological Reviews"},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.molmed.2023.10.001","article-title":"Therapeutic Potential of PANoptosis: Innate Sensors, Inflammasomes, and RIPKs in PANoptosomes","volume":"30","author":"Pandeya A.","year":"2024","journal-title":"Trends in Molecular Medicine"},{"key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.4049\/jimmunol.2200508","article-title":"PANoptosis: a Unique Innate Immune Inflammatory Cell Death Modality","volume":"209","author":"Pandian N.","year":"2022","journal-title":"The Journal of Immunology"},{"key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41586-021-03875-8","article-title":"AIM2 forms a Complex with Pyrin and ZBP1 to Drive PANoptosis and Host Defence","volume":"597","author":"Lee S.","year":"2021","journal-title":"Nature"},{"key":"e_1_2_9_23_1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s13046-024-03089-6","article-title":"Cell Death Shapes Cancer Immunity: Spotlighting PANoptosis","volume":"43","author":"Gao L.","year":"2024","journal-title":"Journal of Experimental & Clinical Cancer Research"},{"key":"e_1_2_9_24_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/s13019-024-02775-y","article-title":"Study on Risk Factors and Treatment Strategies of Hypoxemia after Acute Type a Aortic Dissection Surgery","volume":"19","author":"Yu W.","year":"2024","journal-title":"Journal of Cardiothoracic Surgery"},{"key":"e_1_2_9_25_1","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1080\/0886022X.2022.2113795","article-title":"Risk Factors For Acute Kidney Injury After Stanford Type A Aortic Dissection Repair Surgery: A Systematic Review And Meta\u2010Analysis","volume":"44","author":"Wang L.","year":"2022","journal-title":"Renal Failure"},{"key":"e_1_2_9_26_1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3390\/jcdd12040139","article-title":"Cardiopulmonary Bypass Time during Surgery for Acute Type A Aortic Dissection and Mid\u2010Term Survival","volume":"12","author":"Uimonen M.","year":"2025","journal-title":"Journal of Cardiovascular Development and Disease"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.2337\/dc09-9029","article-title":"American Association of Clinical Endocrinologists and American Diabetes Association Consensus Statement on Inpatient Glycemic Control","volume":"32","author":"Moghissi E. S.","year":"2009","journal-title":"Diabetes Care"},{"key":"e_1_2_9_28_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2023.101808","article-title":"Mitochondria during T Cell Aging","volume":"69","author":"Escrig\u2010Larena J. I.","year":"2023","journal-title":"Seminars in Immunology"},{"key":"e_1_2_9_29_1","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.1038\/s41467-021-24619-2","article-title":"Glucose Limitation Activates AMPK Coupled SENP1\u2010Sirt3 Signalling for T Cell Memory Development","volume":"12","author":"He J.","year":"2021","journal-title":"Nature Communications"},{"key":"e_1_2_9_30_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/SLA.0000000000000688","article-title":"Perioperative Hyperglycemia and Risk of Adverse Events among Patients with and without Diabetes","volume":"261","author":"Kotagal M.","year":"2015","journal-title":"Annals of Surgery"},{"key":"e_1_2_9_31_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ecl.2017.10.005","article-title":"Perioperative Management of Hyperglycemia and Diabetes in Cardiac Surgery Patients","volume":"47","author":"Galindo R. J.","year":"2018","journal-title":"Endocrinology and Metabolism Clinics of North America"},{"key":"e_1_2_9_32_1","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1210\/jc.2015-1959","article-title":"Perioperative Tight Glucose Control Reduces Postoperative Adverse Events in Nondiabetic Cardiac Surgery Patients","volume":"100","author":"Bl\u00e1ha J.","year":"2015","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"e_1_2_9_33_1","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.2337\/db06-0855","article-title":"Intensive Insulin Therapy in Mixed Medical\/Surgical Intensive Care Units: Benefit Versus Harm","volume":"55","author":"Van den Berghe G.","year":"2006","journal-title":"Diabetes"},{"key":"e_1_2_9_34_1","doi-asserted-by":"crossref","first-page":"921","DOI":"10.23736\/S0375-9393.17.11638-X","article-title":"Severe Perioperative Hyperglycemia Attenuates Postoperative Monocytic Function, Basophil Count and T Cell Activation","volume":"83","author":"Lachmann G.","year":"2017","journal-title":"Minerva Anestesiologica"},{"key":"e_1_2_9_35_1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41577-019-0221-9","article-title":"Defining \u2018T Cell Exhaustion\u2019","volume":"19","author":"Blank C. U.","year":"2019","journal-title":"Nature Reviews Immunology"},{"key":"e_1_2_9_36_1","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.30938","article-title":"Long\u2010Term Antigen Exposure Irreversibly Modifies Metabolic Requirements for T Cell Function","volume":"7","author":"Bettonville M.","year":"2018","journal-title":"Elife"},{"key":"e_1_2_9_37_1","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.cell.2016.08.064","article-title":"Succinate Dehydrogenase Supports Metabolic Repurposing Of Mitochondria To Drive Inflammatory Macrophages","volume":"167","author":"Mills E. L.","year":"2016","journal-title":"Cell"},{"key":"e_1_2_9_38_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.817572","article-title":"Succinate\/IL\u20101\u03b2 Signaling Axis Promotes The Inflammatory Progression Of Endothelial And Exacerbates Atherosclerosis","volume":"13","author":"Xu J.","year":"2022","journal-title":"Front Immunol"},{"key":"e_1_2_9_39_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111193","article-title":"Succinate Uptake by T\u00a0Cells Suppresses Their Effector Function via Inhibition of Mitochondrial Glucose Oxidation","volume":"40","author":"Gudgeon N.","year":"2022","journal-title":"Cell Reports"},{"key":"e_1_2_9_40_1","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adf8776","article-title":"The Gene Regulatory Basis Of Bystander Activation in CD8+ T Cells","volume":"9","author":"Watson N. B.","year":"2024","journal-title":"sci Immunol"},{"key":"e_1_2_9_41_1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41467-024-44779-1","article-title":"Mutant KRAS\u2010Activated circATXN7 Fosters Tumor Immunoescape by Sensitizing Tumor\u2010Specific T Cells to Activation\u2010Induced Cell Death","volume":"15","author":"Zhou C.","year":"2024","journal-title":"Nat Commun"},{"key":"e_1_2_9_42_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.5483\/BMBRep.2022.55.2.183","article-title":"Emerging Role Of Bystander T Cell Activation In Autoimmune Diseases","volume":"55","author":"Shim C. H.","year":"2022","journal-title":"BMB Rep"},{"key":"e_1_2_9_43_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1465889","article-title":"Mechanisms Governing Bystander Activation of T Cells","volume":"15","author":"Yosri M.","year":"2024","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_9_44_1","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1161\/CIRCULATIONAHA.120.046464","article-title":"Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis","volume":"144","author":"Edgar L.","year":"2021","journal-title":"Circulation"},{"key":"e_1_2_9_45_1","doi-asserted-by":"crossref","DOI":"10.1093\/cvr\/cvag109","article-title":"Trained Immunity In Monocytes And Macrophages In Atherosclerotic Cardiovascular Disease","volume":"122","author":"Zhang X.","year":"2026","journal-title":"Cardiovascular Research"},{"key":"e_1_2_9_46_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1556\/EuJMI.2.2012.2.1","article-title":"Monocytes in Health and Disease \u2014 Minireview","volume":"2","author":"Karlmark K. R.","year":"2012","journal-title":"European Journal of Microbiology and Immunology"},{"key":"e_1_2_9_47_1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s00467-017-3883-1","article-title":"The Role of Macrophages during Acute Kidney Injury: Destruction and Repair","volume":"34","author":"Han H. I.","year":"2019","journal-title":"Pediatric Nephrology"},{"key":"e_1_2_9_48_1","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.1471-4159.2007.04617.x","article-title":"Characterization and Modeling of Monocyte\u2010Derived Macrophages after Spinal Cord Injury","volume":"102","author":"Longbrake E. E.","year":"2007","journal-title":"Journal of Neurochemistry"},{"key":"e_1_2_9_49_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jtcvs.2015.03.002","article-title":"Surgery for Acute Type A Dissection Using Total Arch Replacement Combined with Stented Elephant Trunk Implantation: Preservation of Autologous Brachiocephalic Vessels","volume":"150","author":"Zhu J. M.","year":"2015","journal-title":"The Journal of Thoracic and Cardiovascular Surgery"},{"key":"e_1_2_9_50_1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jtcvs.2018.08.111","article-title":"Untreated Distal Intimal Tears May be Associated with Paraplegia after Total Arch Replacement and Frozen Elephant Trunk Treatment of Acute Stanford Type A Aortic Dissection","volume":"158","author":"Tan L.","year":"2019","journal-title":"The Journal of Thoracic and Cardiovascular Surgery"},{"key":"e_1_2_9_51_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-89945-3","article-title":"Lack of Recognition and Documentation of Stress Hyperglycemia Is a Disruptor of Optimal Continuity of Care","volume":"11","author":"Moyer E. D.","year":"2021","journal-title":"Scientific Reports"},{"key":"e_1_2_9_52_1","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/S0003-4975(99)01443-5","article-title":"Intraoperative Physiologic Variables and Outcome in Cardiac Surgery: Part II. Neurologic Outcome","volume":"69","author":"Wermeskerken G. K.","year":"2000","journal-title":"Annals of Thoracic Surgery"},{"key":"e_1_2_9_53_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-50582-6","article-title":"Risk Factors of Postoperative Major Adverse Cardiac Events after Radical Cystectomy: Implication of Diastolic Dysfunction","volume":"9","author":"Jun I. J.","year":"2019","journal-title":"Scientific Reports"},{"key":"e_1_2_9_54_1","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1161\/CIRCULATIONAHA.113.006421","article-title":"Standardizing Clinical End Points in Aortic Arch Surgery","volume":"129","author":"Yan T. D.","year":"2014","journal-title":"Circulation"},{"key":"e_1_2_9_55_1","first-page":"118","article-title":"Cerebrovascular Events After Cardiovascular Surgery: Diagnosis, Management and Prevention Strategies","volume":"20","author":"Ferrante M. S.","year":"2023","journal-title":"Kardiochir Torakochirurgia Pol"},{"key":"e_1_2_9_56_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclinane.2024.111676","article-title":"Effect of Inspiratory Oxygen Fraction During Driving Pressure\u2010Guided Ventilation Strategy on Pulmonary Complications Following Open Abdominal Surgery: a Randomized Controlled Trial","volume":"99","author":"Zhang Y. T.","year":"2024","journal-title":"Journal of Clinical Anesthesia"},{"key":"e_1_2_9_57_1","doi-asserted-by":"crossref","DOI":"10.1093\/ejcts\/ezae264","article-title":"Risk Factors and Prognosis of Postoperative Spinal Cord Injury in Type A Aortic Dissection","volume":"66","author":"Wei J.","year":"2024","journal-title":"European Journal of Cardio\u2010Thoracic Surgery"},{"key":"e_1_2_9_58_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-61799-5","article-title":"Postoperative Liver Injury After Sevoflurane or Propofol Anesthesia in Patients Undergoing Non\u2010Cardiac Surgery: A Retrospective Cohort Study","volume":"14","author":"Ryu D. K.","year":"2024","journal-title":"Scientific Reports"},{"key":"e_1_2_9_59_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jtcvs.2014.07.098","article-title":"Frozen Elephant Trunk Surgery in Acute Aortic Dissection","volume":"149","author":"Di Bartolomeo R.","year":"2015","journal-title":"Journal of Thoracic and Cardiovascular Surgery"},{"key":"e_1_2_9_60_1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1186\/s13019-020-01365-y","article-title":"Risk Factors and Long\u2010Term Outcomes of Acute Kidney Injury Complication after Type A Acute Aortic Dissection Surgery in Young Patients","volume":"15","author":"Zong Q.","year":"2020","journal-title":"Journal of Cardiothoracic Surgery"},{"key":"e_1_2_9_61_1","doi-asserted-by":"crossref","DOI":"10.1172\/JCI139298","article-title":"Lymphocyte Crosstalk Is Required for Monocyte\u2010Intrinsic Trained Immunity to Plasmodium Falciparum","volume":"132","author":"Crabtree J. N.","year":"2022","journal-title":"Journal of Clinical Investigation"},{"key":"e_1_2_9_62_1","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1016\/j.immuni.2023.10.004","article-title":"Gasdermin D Permeabilization of Mitochondrial Inner and Outer Membranes Accelerates and Enhances Pyroptosis","volume":"56","author":"Miao R.","year":"2023","journal-title":"Immunity"},{"key":"e_1_2_9_63_1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nprot.2006.478","article-title":"Organelle Isolation: Functional Mitochondria from Mouse Liver, Muscle and Cultured Filroblasts","volume":"2","author":"Frezza C.","year":"2007","journal-title":"Nature Protocols"},{"key":"e_1_2_9_64_1","doi-asserted-by":"crossref","first-page":"4816","DOI":"10.21037\/jtd.2019.10.26","article-title":"Extracellular Mitochondrial DNA Promote NLRP3 Inflammasome Activation and Induce Acute Lung Injury through TLR9 and NF\u2010\u03baB","volume":"11","author":"Wu G.","year":"2019","journal-title":"Journal of Thoracic Disease"},{"key":"e_1_2_9_65_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41586-024-07701-9","article-title":"Inhibition of IL\u201011 Signalling Extends Mammalian Healthspan and Lifespan","volume":"632","author":"Widjaja A. A.","year":"2024","journal-title":"Nature"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.76968","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.76968","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.76968","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:17:09Z","timestamp":1785935829000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.76968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,5]]},"references-count":64,"alternative-id":["10.1002\/advs.76968"],"URL":"https:\/\/doi.org\/10.1002\/advs.76968","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,5]]},"assertion":[{"value":"2025-12-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e76968"}}