{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:47:26Z","timestamp":1785937646398,"version":"3.56.0"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8225024"],"award-info":[{"award-number":["8225024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32401157"],"award-info":[{"award-number":["32401157"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404731"],"award-info":[{"award-number":["82404731"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Atherosclerosis is driven by the persistent crosstalk among chronic inflammation, oxidative stress, and lipid dysmetabolism, largely orchestrated by plaque\u2010resident macrophages. However, therapeutic strategies capable of simultaneously modulating these interconnected pathological processes are still limited. Herein, we developed a hyaluronic acid\u2010coated, copper\u2010doped Prussian blue nanozyme (CuPB@HA) as a CD44\u2010associated plaque\u2010targeted nanotherapeutic. Guided by transcriptomic evidence of CD44 enrichment in atherosclerotic plaque macrophages, HA was incorporated to enhance lesion targeting and cellular internalization. In ox\u2010LDL\u2010stimulated macrophages, CuPB@HA effectively alleviated oxidative stress, suppressed inflammation, and attenuated lipid accumulation. Mechanistically, it reduced CD36\u2010dependent lipid uptake and increased the expression of cholesterol\u2010efflux\u2010related transporters ABCA1 and ABCG1, thereby shifting macrophages away from a pro\u2010inflammatory phenotype. In vivo, CuPB@HA preferentially accumulated within atherosclerotic lesions of ApoE\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice, significantly reducing plaque burden and improving plaque stability\u2010associated histological features. Collectively, CuPB@HA integrates redox regulation, macrophage lipid\u2010handling modulation, and inflammation attenuation, highlighting its potential as a targeted therapeutic strategy for atherosclerosis.\n                  <\/jats:p>","DOI":"10.1002\/advs.76976","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:10:00Z","timestamp":1785935400000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Copper\u2010Doped Prussian Blue Nanozymes With Hyaluronic Acid\u2010Mediated Targeting Alleviate Oxidative Stress and Regulate Cholesterol Handling for Atherosclerosis Therapy"],"prefix":"10.1002","author":[{"given":"Jianliang","family":"Ou","sequence":"first","affiliation":[{"name":"Department of Radiology Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihua","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Changzheng Hospital Naval Medical University  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglu","family":"Zang","sequence":"additional","affiliation":[{"name":"Department of Radiology Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital  Shanghai People's Republic of China"},{"name":"College of Chemistry and Materials Science Shanghai Normal University  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingkang","family":"Wang","sequence":"additional","affiliation":[{"name":"Wuhan United Imaging Life Science Instruments Ltd.  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Sciences Center for Excellence in Molecular Cell Science University of the Chinese Academy of Sciences Chinese Academy of Sciences  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital  Shanghai People's Republic of China"},{"name":"Department of Pharmacy School of Medicine Renji Hospital Shanghai Jiao Tong University  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital  Shanghai People's Republic of 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