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However, the widespread adoption of nanofluidic devices has been hindered by fabrication methods that rely on expensive infrastructure, sophisticated nanofabrication facilities, and labor\u2010intensive processing. Here, we present crackle\u2010lithography, a simple, scalable, and cost\u2010effective approach for fabricating enclosed plastic nanofluidic devices. By harnessing spontaneous crack formation as a lithographic template, highly interconnected nanochannel networks are transferred into polyethylene terephthalate glycol (PETG) substrates through oxygen\u2010plasma etching and subsequently sealed by thermal bonding to produce robust nanofluidic devices. The fabrication strategy is cleanroom\u2010free, highly scalable, and compatible with high\u2010throughput manufacturing, making it attractive for practical implementation. The resulting devices are used for studying molecular transport of gases, water, and ions, exhibit history\u2010dependent ionic conduction with tunable memristive behavior and enable confined electroless copper deposition within the nanochannels. Their high optical transparency further allows real\u2010time fluorescence imaging of transport processes. Together, these results establish crackle\u2010lithography as a versatile and accessible platform for scalable nanofluidic device fabrication with potential applications in sensing, confined chemistry, neuromorphic ionics, and next\u2010generation nanofluidic technologies.<\/jats:p>","DOI":"10.1002\/advs.76980","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T09:43:25Z","timestamp":1786009405000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Scalable Crackle\u2010Lithography for Multifunctional Enclosed Plastic Nanofluidic Devices"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6759-5454","authenticated-orcid":false,"given":"Tirumala Rao","family":"Dumpala","sequence":"first","affiliation":[{"name":"Department of Physics and Astronomy School of Natural Sciences The University of Manchester Oxford Road Manchester UK"},{"name":"Department of Chemistry 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The University of Manchester Booth Street East Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9753-6075","authenticated-orcid":false,"given":"Harry","family":"Whittingham","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy School of Natural Sciences The University of Manchester Oxford Road Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1345-7029","authenticated-orcid":false,"given":"Boya","family":"Radha","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy School of Natural Sciences The University of Manchester Oxford Road Manchester UK"},{"name":"National Graphene Institute The University of Manchester Booth Street East Manchester UK"},{"name":"Photon Science Institute The University of Manchester Oxford Road Manchester 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