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However, engineering frameworks derived from intracellular genetic circuits remain insufficient to capture the ecological, temporal, and spatial dynamics that govern multispecies systems. Here, a symphony\u2010inspired systems\u2010engineering framework is presented for multimicrobial synthetic biology, organizing consortium design across four application\u2010dependent coordination layers: communication, temporal regulation, ecological structuring, and predictive modeling. Building on this framework, a modular engineering blueprint is proposed to guide the rational selection and integration of coordination layers according to engineering objectives, translating systems\u2010level principles into operational strategies for the construction, stabilization, and optimization of synthetic microbial consortia. The manuscript integrates advances in interspecies signaling, oscillatory control, synthetic ecology, hybrid modeling, and real\u2010time monitoring while addressing constraints including metabolite transport, population drift, parameter uncertainty, and process\u2010scale implementation. The proposed framework is modular rather than prescriptive, allowing different coordination layers to be deployed according to application requirements and environmental complexity. By repositioning multimicrobial engineering as a problem of coordinated systems design rather than isolated genetic control, this Perspective provides a structured foundation for the development of synthetic microbial communities across industrial, environmental, and therapeutic applications.<\/jats:p>","DOI":"10.1002\/advs.76981","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:44:43Z","timestamp":1785523483000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Circuits to Symphonies: A Systems\u2010Engineering Blueprint for Multimicrobial Synthetic Biology"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8231-7989","authenticated-orcid":false,"given":"Miguel","family":"Fern\u00e1ndez\u2010Ni\u00f1o","sequence":"first","affiliation":[{"name":"Department of Biotechnology Institute of Agrochemistry and Food Technology (IATA\u2010CSIC)  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2060-8235","authenticated-orcid":false,"given":"Ludger A.","family":"Wessjohann","sequence":"additional","affiliation":[{"name":"Department of Bioorganic Chemistry Leibniz\u2010Institute of Plant Biochemistry (IPB)  Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5414-0787","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Guillam\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Institute of Agrochemistry and Food Technology (IATA\u2010CSIC)  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Burgos\u2010Toro","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Agropecuarias. 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