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Bridging therapy, administered between leukapheresis and CAR\u2010T cell infusion, offers a distinct opportunity to control the disease and precondition the tumor microenvironment without directly exposing CAR\u2010T cells to concomitant drugs. Here, a poly (ADP\u2010ribose) polymerase (PARP) inhibitor combined with anlotinib is evaluated as bridging therapy for ovarian cancer. In immunocompetent mice bearing ovarian tumors, this regimen induces durable intratumoral T cell accumulation associated with activation of the cGAS\u2010STING pathway, vascular normalization, and reduced fibrillar collagen deposition. Furthermore, TGF\u03b2\u2010resistant, dual\u2010target mesothelin (MSLN)\/CD19 CAR\u2010T cells are engineered using a bait\u2010and\u2010switch strategy. Niraparib plus anlotinib administered as bridging therapy before CAR\u2010T cell infusion enhances CAR\u2010T cell infiltration and antitumor activity across multiple preclinical ovarian cancer models. These findings inform an ongoing phase I clinical trial (NCT05141253) evaluating the safety of these engineered CAR\u2010T cells following bridging therapy in patients with refractory MSLN\u2010positive solid tumors. Collectively, our findings support a clinically actionable bridging therapy with translational potential for potentiating CAR\u2010T cell therapy in ovarian cancer and highlight bridging therapy as a translational approach to improve CAR\u2010T cell access and efficacy in solid tumors.<\/jats:p>","DOI":"10.1002\/advs.76994","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T16:04:37Z","timestamp":1786377877000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR\u2010T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1161-4943","authenticated-orcid":false,"given":"Huayi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology National Clinical Research Center for Obstetrics 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