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To address these barriers, rare\u2010earth\u2010doped Nd\n                    <jats:sub>0.02<\/jats:sub>\n                    Fe\n                    <jats:sub>2.98<\/jats:sub>\n                    S\n                    <jats:sub>4<\/jats:sub>\n                    @HA nanozymes (NFSH) are constructed as magneto\u2010NIR\u2010II\u2010programmed cascade nanozymes for trans\u2010BBB delivery, multimodal imaging, and ferroptosis amplification. Hyaluronic acid (HA)\u2010mediated CD44 targeting and oriented magnetic field\u2010enhanced BBB permeability promote tumor enrichment, while Nd\n                    <jats:sup>3+<\/jats:sup>\n                    doping endows NFSH with strengthened superparamagnetism, near\u2010infrared second window (NIR\u2010II) photodynamic activity, and NIR\u2010II fluorescence capability. Under alternating magnetic field (AMF) and NIR\u2010II laser stimulation, NFSH activates catalase\u2010, peroxidase\u2010, glutathione oxidase\u2010, and nicotinamide adenine dinucleotide (NADH) oxidase\u2010like cascade catalysis, which amplifies reactive oxygen species (ROS) production, consumes glutathione, and induces ferroptosis. In the acidic tumor microenvironment, AMF further promotes H\n                    <jats:sub>2<\/jats:sub>\n                    S release, disrupts lysosomal autophagic degradation, and aggravates mitophagy inhibition through NADH depletion\u2010mediated ATP deficiency. This cascade mechanism enhances ferroptosis and reshapes the tumor immune microenvironment by relieving hypoxia and promoting M2\u2010to\u2010M1 macrophage polarization. In addition, NFSH enables NIR\u2010II fluorescence and T\n                    <jats:sub>2<\/jats:sub>\n                    \u2010weighted magnetic resonance imaging for real\u2010time visualization of treatment. This strategy provides an integrated trans\u2010BBB theranostic platform for autophagy\u2010suppressed ferroptosis therapy against GBM.\n                  <\/jats:p>","DOI":"10.1002\/advs.76998","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:13:53Z","timestamp":1785935633000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Magneto\u2010NIR\u2010II\u2010Programmed Cascade Nanozymes Unlocking Blood\u2013Brain Barrier Translocation and Autophagic Resistance in Glioblastoma"],"prefix":"10.1002","volume":"13","author":[{"given":"Ruocan","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering School of Biomedical Engineering School of Pharmaceutical Sciences Hainan University  Haikou China"},{"name":"Key Laboratory of Tropical Biological Resources of Ministry of Education Hainan Engineering Research Center for Drug Screening 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